Water-protein Interactions As a Driver of Phase Separation, Biology, and Disease

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2024 Oct 15

PMID 39402838

Authors

Ethan A Perets

Ty Santiago

Jens Neu

Elsa C Y Yan

Affiliations

Soon will be listed here.

Citing Articles

Structural Dynamics of the Slide Helix of Inactive/Closed Conformation of KirBac1.1 in Micelles and Membranes: A Fluorescence Approach.

Bysack A, Jash C, Raghuraman H J Membr Biol. 2025; 258(1):97-112.

PMID: 39789244 PMC: 11779782. DOI: 10.1007/s00232-024-00335-y.

References

Dec R, Jaworek M, Dzwolak W, Winter R . Liquid-Droplet-Mediated ATP-Triggered Amyloidogenic Pathway of Insulin-Derived Chimeric Peptides: Unraveling the Microscopic and Molecular Processes. J Am Chem Soc. 2023; . DOI: 10.1021/jacs.2c12611. View

Pezzotti S, Sebastiani F, van Dam E, Ramos S, Conti Nibali V, Schwaab G . Spectroscopic Fingerprints of Cavity Formation and Solute Insertion as a Measure of Hydration Entropic Loss and Enthalpic Gain. Angew Chem Int Ed Engl. 2022; 61(29):e202203893. PMC: 9401576. DOI: 10.1002/anie.202203893. View

Pezzotti S, Konig B, Ramos S, Schwaab G, Havenith M . Liquid-Liquid Phase Separation? Ask the Water!. J Phys Chem Lett. 2023; 14(6):1556-1563. DOI: 10.1021/acs.jpclett.2c02697. View

Mukherjee S, Ramos S, Pezzotti S, Kalarikkal A, Prass T, Galazzo L . Entropy Tug-of-War Determines Solvent Effects in the Liquid-Liquid Phase Separation of a Globular Protein. J Phys Chem Lett. 2024; 15(15):4047-4055. PMC: 11033941. DOI: 10.1021/acs.jpclett.3c03421. View

Bag S, Dec R, Pezzotti S, Sahoo R, Schwaab G, Winter R . Unraveling the hydration dynamics of ACCK with ATP: From liquid to droplet to amyloid fibril. Biophys J. 2024; 123(22):3863-3870. PMC: 11617625. DOI: 10.1016/j.bpj.2024.09.011. View

Bansal A, Schmidt M, Rennegarbe M, Haupt C, Liberta F, Stecher S . AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils. Nat Commun. 2021; 12(1):1013. PMC: 7881110. DOI: 10.1038/s41467-021-21129-z. View

Konig B, Pezzotti S, Ramos S, Schwaab G, Havenith M . Real-time measure of solvation free energy changes upon liquid-liquid phase separation of α-elastin. Biophys J. 2023; 123(11):1367-1375. PMC: 11163292. DOI: 10.1016/j.bpj.2023.07.023. View

Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A . Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024; 630(8016):493-500. PMC: 11168924. DOI: 10.1038/s41586-024-07487-w. View

Ahlers J, Adams E, Bader V, Pezzotti S, Winklhofer K, Tatzelt J . The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS. Biophys J. 2021; 120(7):1266-1275. PMC: 8059208. DOI: 10.1016/j.bpj.2021.01.019. View

10.

Bohm F, Schwaab G, Havenith M . Mapping Hydration Water around Alcohol Chains by THz Calorimetry. Angew Chem Int Ed Engl. 2017; 56(33):9981-9985. PMC: 6462811. DOI: 10.1002/anie.201612162. View

11.

Laage D, Elsaesser T, Hynes J . Water Dynamics in the Hydration Shells of Biomolecules. Chem Rev. 2017; 117(16):10694-10725. PMC: 5571470. DOI: 10.1021/acs.chemrev.6b00765. View

12.

Lang X, Shi L, Zhao Z, Min W . Probing the structure of water in individual living cells. Nat Commun. 2024; 15(1):5271. PMC: 11190263. DOI: 10.1038/s41467-024-49404-9. View

13.

Yan E, Perets E, Konstantinovsky D, Hammes-Schiffer S . Detecting Interplay of Chirality, Water, and Interfaces for Elucidating Biological Functions. Acc Chem Res. 2023; 56(12):1494-1504. PMC: 10344471. DOI: 10.1021/acs.accounts.3c00088. View

14.

Leitner D, Gruebele M, Havenith M . Solvation dynamics of biomolecules: modeling and terahertz experiments. HFSP J. 2009; 2(6):314-23. PMC: 2645579. DOI: 10.2976/1.2976661. View

15.

Ramos S, Kamps J, Pezzotti S, Winklhofer K, Tatzelt J, Havenith M . Hydration makes a difference! How to tune protein complexes between liquid-liquid and liquid-solid phase separation. Phys Chem Chem Phys. 2023; 25(41):28063-28069. DOI: 10.1039/d3cp03299j. View