Microbial Imbalance in Darier Disease: Dominance of Various Staphylococcal Species and Absence of Cutibacteria

Overview

Journal Sci Rep

Specialty Science

Date 2024 Oct 14

PMID 39402279

Authors

Dora Plazar

Zseraldin Metyovinyi

Norbert Kiss

Andras Banvolgyi

Nora Makra

Zsuzsanna Dunai

Balazs Mayer

Peter Hollo

Marta Medvecz

Eszter Ostorhazi

Affiliations

Soon will be listed here.

Abstract

Darier disease (DD) is a rare autosomal dominant genodermatosis characterized by erythematous papules and plaques mainly involving sebaceous areas, such as the face, chest and back. Skin microbiome plays an essential role in maintaining skin homeostasis. A disturbed skin microbiome may contribute to the exacerbation of DD. We investigated the bacterial composition of two predilectional sites in DD patients and healthy individuals. We also measured the microbiome composition of deeper skin layers, where diversity was significantly reduced compared to the superficial layer of the skin from the same area. The microbiome of DD patients at lesional sites differed from that of non-lesional skin areas; moreover, non-lesional sites were different from those of the controls. Lesional areas were dominated by Staphylococcus species, such as S. aureus, S. epidermidis, S. hominis, S. sciuri, and S. equorum. However, levels of Cutibacterium acnes (formerly Propionibacterium acnes) and C. acnes subspecies defendens were significantly lower in lesional sites than in non-lesional sites. A significant decrease was measured in the levels of these two bacteria between non-lesional and control samples. Our findings may indicate that alterations in the skin microbiome could contribute to the inflammation of skin lesions in DD.

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