P53 Dependence of Senescence Markers P21v1 and P21v2 in Aging and Acute Injury

Overview

Journal NPJ Aging

Publisher Springer Nature

Specialty Geriatrics

Date 2024 Oct 14

PMID 39402059

Authors

Parmita Kar

Ashok Sivasailam

Rupa Lavarti

Lun Cai

Muthusamy Thangaraju

Emma Nguyen

Bhavishya Mundluru

Raghavan Pillai Raju

Affiliations

Soon will be listed here.

Abstract

The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.

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