Admitted With Epistaxis, Discharged on Immunosuppressants! - An Unusual Presentation of Mixed Connective Tissue Disease
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Abstract
Mixed Connective Tissue Disease (MCTD) is a complex disease that is a combination of several other clinical conditions, including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis/dermatomyositis (PM/DM). What makes MCTD challenging is the fact that there are no current management guidelines. Instead, treatment is usually chosen based on organ involvement using SLE, SSc, and PM/DM guidelines. In this paper, we will discuss an unusual presentation of MCTD, the workup that led to the diagnosis, the immunological profile, and the management plan for this rare disease.
References
1.
Ortega-Hernandez O, Shoenfeld Y
. Mixed connective tissue disease: an overview of clinical manifestations, diagnosis and treatment. Best Pract Res Clin Rheumatol. 2012; 26(1):61-72.
DOI: 10.1016/j.berh.2012.01.009.
View
2.
John K, Sadiq M, George T, Gunasekaran K, Francis N, Rajadurai E
. Clinical and Immunological Profile of Mixed Connective Tissue Disease and a Comparison of Four Diagnostic Criteria. Int J Rheumatol. 2020; 2020:9692030.
PMC: 7204172.
DOI: 10.1155/2020/9692030.
View
3.
Decker P, Moulinet T, Lopez B, Dubucquoi S, Bonnotte B, Lakomy D
. Clinical significance of anti-Ro52 (TRIM21) antibodies in adult patients with connective tissue diseases. Eur J Intern Med. 2021; 91:45-52.
DOI: 10.1016/j.ejim.2021.04.020.
View
4.
Nguyen B, Assassi S, Arnett F, Mayes M
. Association of RNA polymerase III antibodies with scleroderma renal crisis. J Rheumatol. 2010; 37(5):1068.
PMC: 2879023.
DOI: 10.3899/jrheum.091048.
View
5.
Levine S, Raben N, Xie D, Askin F, Tuder R, Mullins M
. Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis Rheum. 2007; 56(8):2729-39.
DOI: 10.1002/art.22790.
View