Variability in Pediatric and Neonatal Organ Offering, Acceptance and Utilization: a Survey of Canadian Pediatric Transplant Programs and Organ Donation Organizations

Overview

Journal Front Transplant

Specialty General Surgery

Date 2024 Oct 14

PMID 39398972

Authors

Laurie A Lee

Augustina Okpere

Dori-Ann Martin

Meagan Mahoney

Lee James

Yaron Avitzur

Bailey Piggott

Christopher Tomlinson

Simon Urschel

Lorraine Hamiwka

Affiliations

Soon will be listed here.

Abstract

Introduction: Solid organ transplantation in children is a lifesaving therapy, however, pediatric organ donation rates remain suboptimal.

Methods: We conducted a cross-sectional survey of Canadian organ donation organizations (ODOs) and pediatric transplant programs (TPs), aiming to describe policies and practices for pediatric organ allocation, acceptance, and utilization in Canada.

Results: Response rates were 82% and 83% respectively for ODOs and transplant programs comprising 7 kidney, 3 heart, 2 lung, 2 liver and 1 intestine programs. All 9 ODOs reported offering pediatric organs following death by neurological criteria (DNC), while 8 reported offering organs following death by circulatory criteria (DCC) for some organs. Variability was found across ODOs and TPs. There was little agreement on both absolute and organ-specific donor exclusion criteria between ODOs. There was further disagreement in organ specific acceptance criteria between ODOs and TPs and between TPs themselves. Notably, despite the development of pediatric donation after DCC guidelines, organs from DCC donors are excluded by many ODOs and TPs.

Discussion: Further variability in pediatric specific training, policies, and allocation guidelines are also documented. Significant areas for improvement in standardization in organ acceptance, offering, and allocation in pediatric donation and transplantation across Canada were identified.

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