Ferroptosis: Potential Therapeutic Targets and Prognostic Predictions for Acute Myeloid Leukemia (Review)

Overview

Journal Oncol Lett

Specialty Oncology

Date 2024 Oct 14

PMID 39397802

Authors

Wenlu Zhang

Wen Wen

Ran Tan

Meirui Zhang

Tantan Zhong

Jianhong Wang

Haiping Chen

Xiaosheng Fang

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a relatively recently discovered type of regulated cell death that is induced by iron-dependent lipid peroxidation. The key contributing factors to ferroptosis are the loss of glutathione peroxidase 4 which is required for reversing lipid peroxidation, the buildup of redox-active iron and the oxidation of phospholipids containing polyunsaturated fatty acids. Ferroptosis has been associated with a number of diseases, including cancers such as hepatocellular carcinoma, breast cancer, acute renal damage and neurological disorders such as Alzheimer's disease and Alzheimer's disease, and there may be an association between ferroptosis and acute myeloid leukemia (AML). The present review aims to describe the primary regulatory pathways of ferroptosis, and the relationship between ferroptosis and the occurrence and development of AML. Furthermore, the present review comprehensively summarizes the latest advances in the treatment and prognosis of ferroptosis in AML.

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