Associations Between Plasma Markers and Symptoms of Anxiety and Depression in Patients with Breast Cancer

Overview

Journal BMC Psychiatry

Publisher Biomed Central

Specialty Psychiatry

Date 2024 Oct 11

PMID 39394561

Authors

Yibo He

Shangping Cheng

Lingrong Yang

Lingyu Ding

Yidan Chen

Jing Lu

Ruzhen Zheng

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Among patients with solid tumors, those with breast cancer (BC) experience the most severe psychological issues, exhibiting a high global prevalence of depression that negatively impacts prognosis. Depression can be easily missed, and clinical markers for its diagnosis are lacking. Therefore, this study in order to investigate the diagnostic markers for BC patients with depression and anxiety and explore the specific changes of metabolism.

Method And Results: Thirty-eight BC patients and thirty-six matched healthy controls were included in the study. The anxiety and depression symptoms of the participants were evaluated by the 17-item Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA). Plasma levels of glial fibrillary acidic protein (GFAP) and lipocalin-2 (LCN2) were evaluated using enzyme linked immunosorbent assay, and plasma lactate levels and metabolic characteristics were analyzed.

Conclusion: This study revealed that GFAP and LCN2 may be good diagnostic markers for anxiety or depression in patients with BC and that plasma lactate levels are also a good diagnostic marker for anxiety. In addition, specific changes in metabolism in patients with BC were preliminarily explored.

Citing Articles

Characteristics of positive and negative effects on the quality of life of breast cancer patients.

Zhao J, Yang D, Liu Y, Wu Y, Chen C, Li J BMC Psychiatry. 2024; 24(1):926.

PMID: 39696113 PMC: 11657455. DOI: 10.1186/s12888-024-06311-z.

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