Study of the Significance of the Combination of the Fibrinogen-albumin Ratio and Sarcopenia in Predicting the Prognosis of Laryngeal Cancer Patients Undergoing Radical Surgery

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2024 Oct 11

PMID 39394062

Authors

Yizheng Zhang

Zhiyong Meng

Ming Lu

Shenjiong Ruan

Jiao Zhou

Mingchen Zhang

Yanjun Huang

Kehui Chen

Xinyuan Luo

Cheng-Ke Xie

Chaohui Zheng

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to investigate how the impact of preoperative sarcopenia and inflammatory markers for laryngeal cancer patients and develop a new scoring system to predict their prognosis.

Materials And Methods: Patients who underwent laryngectomy for laryngeal cancer (LC) from December 2015 to December 2020 at the Second Affiliated Hospital of Fujian Medical University were included. Independent prognostic factors were determined using univariate and multivariate analyses. A new scoring system (SFAR) was established based on FAR and preoperative sarcopenia, and statistically analyzed.

Results: 198 cases included in this study that met the admission criteria. Multivariate analysis shown that preoperative sarcopenia, pTNM stage, and FAR were independent prognostic factors for laryngeal cancer. Based on these three indicators, we developed the SFAR scoring system. Multivariate analysis showed that SFAR was an independent predictor of laryngeal cancer (p < 0.001). SFAR was then incorporated into a prognostic model that included T-stage and N-stage, and a column-line graph was generated to accurately predict its survival.

Conclusion: Systemic inflammation and sarcopenia are significantly associated with postoperative prognosis in laryngeal cancer. A new scoring system (SFAR) had implications for improving the prognosis of patients undergoing surgery for laryngeal cancer.

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