Exploring Copper's Role in Stroke: Progress and Treatment Approaches

Overview

Journal Front Pharmacol

Date 2024 Oct 11

PMID 39391696

Authors

Gang Peng

Yongpan Huang

Guangdi Xie

Jiayu Tang

Affiliations

Soon will be listed here.

Abstract

Copper is an important mineral, and moderate copper is required to maintain physiological processes in nervous system including cerebral ischemia/reperfusion (I/R) injury. Over the past few decades, copper induced cell death, named cuprotosis, has attracted increasing attention. Several lines of evidence have confirmed cuprotosis exerts pivotal role in diverse of pathological processes, such as cancer, neurodegenerative diseases, and I/R injury. Therefore, an in-depth understanding of the interaction mechanism between copper-mediated cell death and I/R injury may reveal the significant alterations about cellular copper-mediated homeostasis in physiological and pathophysiological conditions, as well as therapeutic strategies deciphering copper-induced cell death in cerebral I/R injury.

Citing Articles

Cerebrovascular accident and essential and toxic metals: cluster analysis and principal component analysis.

Nezami H, Kooshki A, Esmaily H, Sanjari M, Ahmadi Z, Sadeghi M BMC Pharmacol Toxicol. 2025; 26(1):2.

PMID: 39748431 PMC: 11697480. DOI: 10.1186/s40360-024-00833-8.

References

Bhattacharjee A, Ghosh S, Chatterji A, Chakraborty K . Neuron-glia: understanding cellular copper homeostasis, its cross-talk and their contribution towards neurodegenerative diseases. Metallomics. 2020; 12(12):1897-1911. DOI: 10.1039/d0mt00168f. View

Li X, Dehghan M, Tse L, Lang X, Rangarajan S, Liu W . Associations of dietary copper intake with cardiovascular disease and mortality: findings from the Chinese Perspective Urban and Rural Epidemiology (PURE-China) Study. BMC Public Health. 2023; 23(1):2525. PMC: 10726617. DOI: 10.1186/s12889-023-17441-6. View

Fetherolf M, Boyd S, Taylor A, Kim H, Wohlschlegel J, Blackburn N . Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site. J Biol Chem. 2017; 292(29):12025-12040. PMC: 5519355. DOI: 10.1074/jbc.M117.775981. View

Chakraborty K, Kar S, Rai B, Bhagat R, Naskar N, Seth P . Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia. Metallomics. 2022; 14(4). PMC: 8975716. DOI: 10.1093/mtomcs/mfac005. View

Scheiber I, Mercer J, Dringen R . Metabolism and functions of copper in brain. Prog Neurobiol. 2014; 116:33-57. DOI: 10.1016/j.pneurobio.2014.01.002. View

Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C . The molecular mechanisms of copper metabolism and its roles in human diseases. Pflugers Arch. 2020; 472(10):1415-1429. DOI: 10.1007/s00424-020-02412-2. View

Swaminathan A, Gohil V . The Role of COA6 in the Mitochondrial Copper Delivery Pathway to Cytochrome Oxidase. Biomolecules. 2022; 12(1). PMC: 8773535. DOI: 10.3390/biom12010125. View

Slezak J, Kura B, LeBaron T, Singal P, Buday J, Barancik M . Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine. Curr Pharm Des. 2020; 27(5):610-625. DOI: 10.2174/1381612826666200821114016. View

Akerfeldt M, Tran C, Shen C, Hambley T, New E . Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells. J Biol Inorg Chem. 2017; 22(5):765-774. DOI: 10.1007/s00775-017-1467-y. View

10.

An Y, Li S, Huang X, Chen X, Shan H, Zhang M . The Role of Copper Homeostasis in Brain Disease. Int J Mol Sci. 2022; 23(22). PMC: 9698384. DOI: 10.3390/ijms232213850. View

11.

Samygina V, Sokolov A, Bourenkov G, Schneider T, Anashkin V, Kozlov S . Rat ceruloplasmin: a new labile copper binding site and zinc/copper mosaic. Metallomics. 2017; 9(12):1828-1838. DOI: 10.1039/c7mt00157f. View

12.

Yang S, Li Y, Zhou L, Wang X, Liu L, Wu M . Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies. Cell Death Discov. 2024; 10(1):25. PMC: 10787750. DOI: 10.1038/s41420-023-01796-1. View

13.

Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C . Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis. Redox Biol. 2023; 69:103007. PMC: 10788306. DOI: 10.1016/j.redox.2023.103007. View

14.

Bonaccorsi di Patti M, Cutone A, Nemcovic M, Pakanova Z, Barath P, Musci G . Production of Recombinant Human Ceruloplasmin: Improvements and Perspectives. Int J Mol Sci. 2021; 22(15). PMC: 8347646. DOI: 10.3390/ijms22158228. View

15.

Braymer J, Freibert S, Rakwalska-Bange M, Lill R . Mechanistic concepts of iron-sulfur protein biogenesis in Biology. Biochim Biophys Acta Mol Cell Res. 2020; 1868(1):118863. DOI: 10.1016/j.bbamcr.2020.118863. View

16.

Ma H, Zhang H, Zuo Z, Liu Y . Heterogeneous organization of Locus coeruleus: An intrinsic mechanism for functional complexity. Physiol Behav. 2023; 268:114231. DOI: 10.1016/j.physbeh.2023.114231. View

17.

Kuckova L, Jomova K, Svorcova A, Valko M, Segla P, Moncol J . Synthesis, crystal structure, spectroscopic properties and potential biological activities of salicylate‒neocuproine ternary copper(II) complexes. Molecules. 2015; 20(2):2115-37. PMC: 6272241. DOI: 10.3390/molecules20022115. View

18.

Gorska A, Markiewicz-Gospodarek A, Markiewicz R, Chilimoniuk Z, Borowski B, Trubalski M . Distribution of Iron, Copper, Zinc and Cadmium in Glia, Their Influence on Glial Cells and Relationship with Neurodegenerative Diseases. Brain Sci. 2023; 13(6). PMC: 10296676. DOI: 10.3390/brainsci13060911. View

19.

Trist B, Hilton J, Hare D, Crouch P, Double K . Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic. Angew Chem Int Ed Engl. 2020; 60(17):9215-9246. PMC: 8247289. DOI: 10.1002/anie.202000451. View

20.

Li B, Yu W, Verkhratsky A . Trace metals and astrocytes physiology and pathophysiology. Cell Calcium. 2024; 118:102843. DOI: 10.1016/j.ceca.2024.102843. View