Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry - A Review

Overview

Journal Eng Life Sci

Specialty Biomedical Engineering

Date 2024 Oct 11

PMID 39391272

Authors

Saseendran Shalu

Panam Kunnel Raveendranathan Karthikanath

Vinoth Kumar Vaidyanathan

Lars M Blank

Andrea Germer

Palanisamy Athiyaman Balakumaran

Affiliations

Soon will be listed here.

Abstract

Squalene is a natural triterpenoid and a biosynthetic precursor of steroids and hopanoids in microorganisms, plants, humans, and other animals. Squalene has exceptional properties, such as its antioxidant activity, a high penetrability of the skin, and the ability to trigger the immune system, promoting its application in the cosmetic, sustenance, and pharmaceutical industries. Because sharks are the primary source of squalene, there is a need to identify low-cost, environment friendly, and sustainable alternatives for producing squalene commercially. This shift has prompted scientists to apply biotechnological advances to research microorganisms for synthesizing squalene. This review summarizes recent metabolic and bioprocess engineering strategies in various microorganisms for the biotechnological production of this valuable molecule.

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