A Receptor for Dual Ligands Governs Plant Immunity and Hormone Response and is Targeted by a Nematode Effector

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2024 Oct 10

PMID 39388275

Authors

Li Huang

Yulin Yuan

Chloe Ramirez

Zhe Zhao

Letian Chen

Thomas Griebel

Joanna Kud

Joseph C Kuhl

Allan Caplan

Louise-Marie Dandurand

Fangming Xiao

Affiliations

Soon will be listed here.

Abstract

In this study, we show that the potato () pattern recognition receptor (PRR) NEMATODE-INDUCED LEUCINE-RICH REPEAT (LRR)-RLK1 (StNILR1) functions as a dual receptor, recognizing both nematode-associated molecular pattern ascaroside #18 (Ascr18) and plant hormone brassinosteroid (BR) to activate two different physiological outputs: pattern-triggered immunity (PTI) and BR response. Ascr18/BR-StNILR1 signaling requires the coreceptor potato BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (StBAK1) and perception of either ligand strengthens StNILR1 interaction with StBAK1 in plant cells. Significantly, the parasitically successful potato cyst nematode () utilizes the effector RHA1B, which is a functional ubiquitin ligase, to target StNILR1 for ubiquitination-mediated proteasome-dependent degradation, thereby countering Ascr18/BR-StNILR1-mediated PTI in potato and facilitating nematode parasitism. These findings broaden our understanding of PRR specificity and reveal a nematode parasitic mechanism that targets a PTI signaling pathway.

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