Adjuvant Antimicrobial Photodynamic Therapy Improves Periodontal Health and Reduces Inflammatory Cytokines in Patients with Type 1 Diabetes Mellitus

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2024 Oct 9

PMID 39383343

Authors

Paula de Oliveira Cunha

Isabela Rodrigues Gonsales

Sebastiao Luiz Aguiar Greghi

Adriana Campos Passanezi Santana

Heitor Marques Honorio

Carlos Antonio Negrato

Mariana Schutzer Ragghianti Zangrando

Carla Andreotti Damante

Affiliations

Soon will be listed here.

Abstract

Background: Antimicrobial photodynamic therapy (aPDT) is an adjuvant treatment to scaling and root planing (SRP) which improves periodontal health. It may be beneficial to patients with systemic diseases, such as type 1 diabetes mellitus.

Objective: This randomized clinical trial evaluated the adjunctive effect of aPDT on the periodontal treatment of patients with type 1 diabetes (T1D).

Methodology: 38 patients were included in the study and divided into four groups: DSRP - T1D patients treated with SRP; CSRP - normoglycemic patients treated with SRP; DPDT - T1D patients treated with SRP + aPDT (methylene blue and red laser); CPDT - normoglycemic patients treated with SRP + aPDT. , Periodontal clinical parameters and inflammatory cytokines in crevicular fluid were recorded at baseline and then after 1, 3 and 6 months. The clinical endpoint for treatment was evaluated after 6 months.

Results: Adjuvant aPDT treatment resulted in reduction of probing depth after 3 months (0.38 mm - p<0.05) on T1D patients and in control group after 6 months (0.66 mm - p<0.05). Reduction of clinical attachment levels was similar for both treatments in control patients (p>0.05). There was a significant reduction of TNF-α in crevicular fluid in both groups treated with aPDT (p<0.05). The T1D (65%) and normoglycemic (72%) groups achieved the clinical endpoint after both treatments (p>0.05).

Conclusions: Adjuvant aPDT provided additional benefits in improving periodontal clinical parameters and reducing inflammatory cytokines in both T1D and normoglycemic patients. However, normoglycemic patients showed greater clinical improvements compared to T1D patients following adjuvant aPDT treatment.

Citing Articles

An Attempt to Use Virtual Reality as a Tool to Reduce Patient Anxiety During Dental Treatment.

Ledwon A, Debski P, Jedrusik P, Mielcarska S, Misiolek H, Meisner M J Clin Med. 2024; 13(22).

PMID: 39597976 PMC: 11594890. DOI: 10.3390/jcm13226832.

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