Linking Hearts and Minds: Understanding the Cardiovascular Impact of Bipolar Disorder

Overview

Journal Future Cardiol

Specialty Cardiology & Vascular Diseases

Date 2024 Oct 9

PMID 39382013

Authors

Darshini Shah

Bhupinder Singh

Fnu Varnika

Fremita Chelsea Fredrick

Anish Kumar Reddy Meda

Kanishk Aggarwal

Rohit Jain

Affiliations

Soon will be listed here.

Abstract

Bipolar disorder is a severe and recurring condition that has become a significant public health issue globally. Studies indicate a heightened risk and earlier onset of cardiovascular diseases among individuals with bipolar disorder, potentially increasing mortality rates. The chronic nature of bipolar disorder leads to disturbances across multiple systems, including autonomic dysfunction, over-activation of the hypothalamic-pituitary-adrenal axis and increased levels of peripheral inflammatory markers. These disruptions cause endothelial damage, the formation of plaques and blood clots, in addition to the medications used to treat bipolar disorder and genetic associations contributing to cardiovascular disease development. Understanding the complex interplay between bipolar disorder and cardiovascular events is essential for the prevention and effective management of cardiovascular conditions in individuals with bipolar disorder.

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