Possible Roles of Neuropeptide/transmitter and Autoantibody Modulation in Emotional Problems and Aggression

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2024 Oct 9

PMID 39381606

Authors

Henning Vaeroy

Regina Skar-Froding

Elin Hareton

Serguei O Fetissov

Affiliations

Soon will be listed here.

Abstract

The theoretical foundations of understanding psychiatric disorders are undergoing changes. Explaining behaviour and neuroendocrine cell communication leaning towards immunology represents a different approach compared to previous models for understanding complex central nervous system processes. One such approach is the study of immunoglobulins or autoantibodies, and their effect on peptide hormones in the neuro-endocrine system. In the present review, we provide an overview of the literature on neuropeptide/transmitter and autoantibody modulation in psychiatric disorders featuring emotional problems and aggression, including associated illness behaviour. Finally, we discuss the role of psycho-immunology as a growing field in the understanding of psychiatric disorders, and that modulation and regulation by IgG autoAbs represent a relatively new subcategory in psycho-immunology, where studies are currently being conducted.

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