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Management of PFO in Paradoxical Embolic Stroke with Hemorrhagic Conversion: a Case Report

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Abstract

A paradoxical embolism is defined as a venous thrombus that crosses through a heart defect, into the systemic circulation, usually through a patent foramen ovale. Treatment varies between closure of patent foramen ovale vs. medical management based on a variety of individual risk factors and the cardiac defect's characteristics. We describe a case of paradoxical stroke complicated by hemorrhagic conversion, ultimately requiring an IVC filter.

References
1.
Mazya M, Egido J, Ford G, Lees K, Mikulik R, Toni D . Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. Stroke. 2012; 43(6):1524-31. DOI: 10.1161/STROKEAHA.111.644815. View

2.
Robbins N, Swanson R . Opposing effects of glucose on stroke and reperfusion injury: acidosis, oxidative stress, and energy metabolism. Stroke. 2014; 45(6):1881-6. PMC: 4102697. DOI: 10.1161/STROKEAHA.114.004889. View

3.
Zhang X, Cao X, Xu X, Li A, Xu Y . Correlation between the -1562C/T polymorphism in the matrix metalloproteinase-9 gene and hemorrhagic transformation of ischemic stroke. Exp Ther Med. 2015; 9(3):1043-1047. PMC: 4316928. DOI: 10.3892/etm.2015.2186. View

4.
Elgendy A, Saver J, Amin Z, Boudoulas K, Carroll J, Elgendy I . Proposal for Updated Nomenclature and Classification of Potential Causative Mechanism in Patent Foramen Ovale-Associated Stroke. JAMA Neurol. 2020; 77(7):878-886. DOI: 10.1001/jamaneurol.2020.0458. View

5.
Saver J, Mattle H, Thaler D . Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Ischemic Stroke: A Topical Review. Stroke. 2018; 49(6):1541-1548. DOI: 10.1161/STROKEAHA.117.018153. View