Advanced Tractography-guided Laser Ablation of a Perirolandic Long-term Epilepsy-associated Tumor: Illustrative Case

Overview

Journal J Neurosurg Case Lessons

Specialty Neurology

Date 2024 Oct 8

PMID 39378521

Authors

Joseph Yuan-Mou Yang

Rachel Cottier

Richard Beare

Sila Genc

Paola Diadori

Alexander Ngo

Ella Sahlas

Boris C Bernhardt

Gabrielle Arbour

Alain Bouthillier

Aristides Hadjinicolaou

Alexander G Weil

Affiliations

Soon will be listed here.

Abstract

Background: Microsurgical resection of drug-resistant epilepsy-associated perirolandic lesions can lead to postoperative motor impairment. Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRgLITT) has emerged as a less invasive alternative, offering reduced surgical risks and improved neurological outcomes. Electrophysiological tools routinely used for motor mapping in resective microsurgery are incompatible with intraoperative MRI. The utilization of advanced neuroimaging adjuncts for eloquent brain mapping during MRgLITT is imperative. The authors present the case of a 17-year-old athlete who underwent MRgLITT for a perirolandic long-term epilepsy-associated tumor (LEAT). They performed probabilistic multi-tissue constrained spherical deconvolution (MT-CSD) tractography to delineate the corticospinal tract (CST) for presurgical planning and intraoperative image guidance. The CST tractography was integrated into neuronavigation and MRgLITT workstation software to guide the ablation while monitoring the CST throughout the procedure.

Observations: The integration of CST tractography into neuronavigation workstation planning and laser ablation workstation thermoablation is feasible and practical, facilitating complete ablation of a deep-seated perirolandic LEAT while preserving motor function.

Lessons: Probabilistic MT-CSD tractography enhanced MRgLITT planning as well as intraprocedural CST visualization and preservation, leading to a favorable functional outcome. The limitations of tractography and the predictability of thermal output distribution compared to the gold standard of microsurgical resection merit further discussion. https://thejns.org/doi/10.3171/CASE24139.

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