Ferroptosis: a New Mechanism of Traditional Chinese Medicine for Treating Hematologic Malignancies

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Oct 8

PMID 39376985

Authors

Xinyue Gou

Xudong Tang

Chi Liu

Zhuo Chen

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a recently identified form of cell death characterized by lipid peroxidation and elevated iron levels. It is closely associated with hematologic malignancies, including leukemia, multiple myeloma (MM), and myelodysplastic syndromes (MDS). Research indicates that ferroptosis could represent a novel therapeutic target for these hematologic malignancies. Furthermore, traditional Chinese medicine (TCM) has been shown to modulate hematologic malignancies through the ferroptosis pathway. This paper aims to elucidate the mechanisms underlying ferroptosis and summarize the current research advancements regarding ferroptosis in hematologic malignancies, as well as the role of traditional Chinese medicine in the prevention and treatment of ferroptosis, with the goal of enhancing treatment efficacy.

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