Roles of Exosomal MiRNAs in Asthma: Mechanisms and Applications

Overview

Journal J Asthma Allergy

Publisher Dove Medical Press

Date 2024 Oct 8

PMID 39376731

Authors

Xiaoxue Liu

Jiawei Gao

Liuxin Yang

Xingxing Yuan

Affiliations

Soon will be listed here.

Abstract

Asthma is a chronic inflammatory disorder of the airways, characterized by a complex interplay of genetic, environmental, and immunological factors that contribute to its onset and progression. Recent advances in researches have illuminated the critical role of exosomal microRNAs (miRNAs) in the pathogenesis and development of asthma. Exosomes are nano-sized extracellular vesicles that facilitate intercellular communication by transporting a variety of bioactive molecules, including miRNAs, and play a crucial role in regulating gene expression and immune responses, which are central to the inflammatory processes underlying asthma. Exosomal miRNAs are emerging as key players in asthma due to their involvement in various aspects of the disease, including the regulation of inflammation, airway hyperresponsiveness, and remodeling. Their ability to influence the behavior of target cells and tissues makes them valuable both as diagnostic biomarkers and as potential therapeutic targets. This review aims to provide a comprehensive overview of the biogenesis of exosomes, the functional roles of exosomal miRNAs in asthma, and their clinical potential. It will explore the mechanisms by which these miRNAs contribute to asthma pathophysiology, discuss their utility in diagnosing and monitoring the disease, and highlight ongoing research efforts to harness their therapeutic potential.

References

McDowell P, Heaney L . Different endotypes and phenotypes drive the heterogeneity in severe asthma. Allergy. 2019; 75(2):302-310. DOI: 10.1111/all.13966. View

Dai Y, Li Y, Cheng R, Gao J, Li Y, Lou C . TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells. Biomed Pharmacother. 2018; 101:24-29. DOI: 10.1016/j.biopha.2018.02.057. View

Papi A, Brightling C, Pedersen S, Reddel H . Asthma. Lancet. 2017; 391(10122):783-800. DOI: 10.1016/S0140-6736(17)33311-1. View

Shang L, Wang L, Shi X, Wang N, Zhao L, Wang J . HMGB1 was negatively regulated by HSF1 and mediated the TLR4/MyD88/NF-κB signal pathway in asthma. Life Sci. 2019; 241:117120. DOI: 10.1016/j.lfs.2019.117120. View

Paciencia I, Sharma N, Hugg T, Rantala A, Heibati B, Al-Delaimy W . The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review. Environ Health Perspect. 2024; 132(6):66001. PMC: 11218706. DOI: 10.1289/EHP13948. View

Levanen B, Bhakta N, Paredes P, Barbeau R, Hiltbrunner S, Pollack J . Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013; 131(3):894-903. PMC: 4013392. DOI: 10.1016/j.jaci.2012.11.039. View

Olivieri B, Gunaydin F, Corren J, Senna G, Durham S . The combination of allergen immunotherapy and biologics for inhalant allergies: Exploring the synergy. Ann Allergy Asthma Immunol. 2024; . DOI: 10.1016/j.anai.2024.06.016. View

Wang H, Zhong B, Geng Y, Hao J, Jin Q, Zhang Y . TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway. Respir Res. 2021; 22(1):238. PMC: 8393827. DOI: 10.1186/s12931-021-01826-5. View

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

10.

Li C, Deng C, Zhou T, Hu J, Dai B, Yi F . MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis. Int J Biol Sci. 2021; 17(7):1795-1807. PMC: 8120458. DOI: 10.7150/ijbs.59715. View

11.

Ramsahai J, Hansbro P, Wark P . Mechanisms and Management of Asthma Exacerbations. Am J Respir Crit Care Med. 2018; 199(4):423-432. DOI: 10.1164/rccm.201810-1931CI. View

12.

Bahmer T, Krauss-Etschmann S, Buschmann D, Behrends J, Watz H, Kirsten A . RNA-seq-based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma. Allergy. 2020; 76(1):366-371. PMC: 7818394. DOI: 10.1111/all.14486. View

13.

Liu J, Li C, Zhang C, Zhang Z . LncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3K/AKT signaling pathway by targeting miR-21 in severe asthma. Pulmonology. 2019; 26(1):18-26. DOI: 10.1016/j.pulmoe.2019.07.001. View

14.

Bencivenga D, Stampone E, Roberti D, Della Ragione F, Borriello A . p27, an Intrinsically Unstructured Protein with Scaffold Properties. Cells. 2021; 10(9). PMC: 8465030. DOI: 10.3390/cells10092254. View

15.

Schoettler N, Strek M . Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine. Chest. 2019; 157(3):516-528. PMC: 7609962. DOI: 10.1016/j.chest.2019.10.009. View

16.

Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W . RAB31 marks and controls an ESCRT-independent exosome pathway. Cell Res. 2020; 31(2):157-177. PMC: 8027411. DOI: 10.1038/s41422-020-00409-1. View

17.

Heffler E, Allegra A, Pioggia G, Picardi G, Musolino C, Gangemi S . MicroRNA Profiling in Asthma: Potential Biomarkers and Therapeutic Targets. Am J Respir Cell Mol Biol. 2017; 57(6):642-650. DOI: 10.1165/rcmb.2016-0231TR. View

18.

Tang B, Wu Y, Zhang Y, Cheng Y, Wu Y, Fang H . Scorpion and centipede alleviates severe asthma through M2 macrophage-derived exosomal miR-30b-5p. Aging (Albany NY). 2022; 14(9):3921-3940. PMC: 9134957. DOI: 10.18632/aging.204053. View

19.

Halwani R, Al-Muhsen S, Al-Jahdali H, Hamid Q . Role of transforming growth factor-β in airway remodeling in asthma. Am J Respir Cell Mol Biol. 2010; 44(2):127-33. DOI: 10.1165/rcmb.2010-0027TR. View

20.

Sastre B, Canas J, Rodrigo-Munoz J, Del Pozo V . Novel Modulators of Asthma and Allergy: Exosomes and MicroRNAs. Front Immunol. 2017; 8:826. PMC: 5519536. DOI: 10.3389/fimmu.2017.00826. View