High Risk Human Papillomavirus Prevalence in Patients with Hypopharynx Cancer of Northeast India: A Pilot Study

Overview

Journal Indian J Otolaryngol Head Neck Surg

Publisher Springer

Date 2024 Oct 8

PMID 39376266

Authors

Manigreeva Krishnatreya

Avdhesh Kumar Rai

Mouchumee Bhattacharyya

Tashnin Rahman

Plabita Bhuyan

Anupam Sarma

Affiliations

Soon will be listed here.

Abstract

Oncogenic viruses such as, Human papillomavirus (HPV) associated head and neck cancers have been considered to represent different etiological and pathological behaviour. This pilot study was conceived to investigate high risk HPV (hr-HPV) infection and its association with life style habits such as tobacco, alcohol consumption in patients with hypopharynx cancer from North -East India. A total of thirty four primary hypopharynx cancer biopsy specimens were collected. These samples were analysed for hr-HPV DNA using nested multiplex PCR (NMPCR). The lifestyle and dietary associated factors were collected through a self- designed questionnaire. The presence of hr-HPV was confirmed in 50% ( = 17) patients with hypopharynx cancer by nested multiplex PCR (NMPCR). Among hr-HPV positive cases, only HPV- 16 genotype was found. Significant association was observed between hr-HPV infections with alcohol consumption (p-0.025), alcohol with tobacco habit (p-0.01). Our study demonstrated that alcohol consumption, tobacco chewing may act as risk factors for hr-HPV infection in a subset of patients with hypopharynx cancer from the North-East region of India.

References

Schabath M, Thompson Z, Egan K, Torres B, Nguyen A, Papenfuss M . Alcohol consumption and prevalence of human papillomavirus (HPV) infection among US men in the HPV in Men (HIM) study. Sex Transm Infect. 2014; 91(1):61-7. PMC: 4342055. DOI: 10.1136/sextrans-2013-051422. View

Bosch F, Lorincz A, Munoz N, Meijer C, Shah K . The causal relation between human papillomavirus and cervical cancer. J Clin Pathol. 2002; 55(4):244-65. PMC: 1769629. DOI: 10.1136/jcp.55.4.244. View

van Monsjou H, Balm A, van den Brekel M, Wreesmann V . Oropharyngeal squamous cell carcinoma: a unique disease on the rise?. Oral Oncol. 2010; 46(11):780-5. DOI: 10.1016/j.oraloncology.2010.08.011. View

Girja K, Sundharam B, Krishnan P, Devi C . Biochemical changes of saliva in tobacco chewers tobacco smokers, alcohol consumers, leukoplakia and oral cancer patients. Indian J Dent Res. 2002; 13(2):102-7. View

Mignogna M, Fedele S, Russo L . The World Cancer Report and the burden of oral cancer. Eur J Cancer Prev. 2004; 13(2):139-42. DOI: 10.1097/00008469-200404000-00008. View

Kumar R, Rai A, Das D, Das R, Kumar R, Sarma A . Alcohol and Tobacco Increases Risk of High Risk HPV Infection in Head and Neck Cancer Patients: Study from North-East Region of India. PLoS One. 2015; 10(10):e0140700. PMC: 4608822. DOI: 10.1371/journal.pone.0140700. View

Zur Hausen H, de Villiers E . Cancer "causation" by infections--individual contributions and synergistic networks. Semin Oncol. 2014; 41(6):860-75. DOI: 10.1053/j.seminoncol.2014.10.003. View

Pande P, Soni S, Kaur J, Agarwal S, Mathur M, Shukla N . Prognostic factors in betel and tobacco related oral cancer. Oral Oncol. 2002; 38(5):491-9. DOI: 10.1016/s1368-8375(01)00090-2. View

Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M . HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement. Am J Surg Pathol. 2023; 47(9):955-966. DOI: 10.1097/PAS.0000000000002086. View

10.

Heinzel P, Balaram P, Bernard H . Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers. Int J Cancer. 1996; 68(4):420-3. DOI: 10.1002/(SICI)1097-0215(19961115)68:4<420::AID-IJC3>3.0.CO;2-2. View

11.

Zur Hausen H . Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002; 2(5):342-50. DOI: 10.1038/nrc798. View

12.

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

13.

Krishnatreya M, Chandra Kataki A, Sharma J, Baishya N, Rahman T, Bhattcharyya M . A Survival Analysis of Hypopharyngeal Cancer Patients: A Hospital-Cancer registry Based Study. Indian J Otolaryngol Head Neck Surg. 2019; 71(Suppl 1):798-804. PMC: 6848493. DOI: 10.1007/s12070-018-1556-4. View

14.

Ha P, Califano J . The role of human papillomavirus in oral carcinogenesis. Crit Rev Oral Biol Med. 2004; 15(4):188-96. DOI: 10.1177/154411130401500402. View

15.

Smith E, Hoffman H, Summersgill K, Kirchner H, Turek L, Haugen T . Human papillomavirus and risk of oral cancer. Laryngoscope. 1998; 108(7):1098-103. DOI: 10.1097/00005537-199807000-00027. View

16.

Syrjanen K, Syrjanen S, Lamberg M, Pyrhonen S, Nuutinen J . Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. Int J Oral Surg. 1983; 12(6):418-24. DOI: 10.1016/s0300-9785(83)80033-7. View

17.

Nair S, Pillai M . Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis. 2005; 11(6):350-9. DOI: 10.1111/j.1601-0825.2005.01127.x. View

18.

Gillison M, Koch W, Capone R, Spafford M, Westra W, Wu L . Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000; 92(9):709-20. DOI: 10.1093/jnci/92.9.709. View

19.

Balaram P, Nalinakumari K, Abraham E, Balan A, Hareendran N, Bernard H . Human papillomaviruses in 91 oral cancers from Indian betel quid chewers--high prevalence and multiplicity of infections. Int J Cancer. 1995; 61(4):450-4. DOI: 10.1002/ijc.2910610403. View

20.

Miller C, White D . Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma: a retrospective review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996; 82(1):57-68. DOI: 10.1016/s1079-2104(96)80378-7. View