Human Pegivirus -1 (HPgV-1) RNA Frequency and Genotype Distribution in Pediatric Oncology Patients with Febrile Neutropenia

Overview

Journal Virus Res

Specialty Microbiology

Date 2024 Oct 7

PMID 39374843

Authors

Anielly Sarana da Silva

Gabriel Montenegro de Campos

Gabriela Marengone Altizani

Alice Chagas Barros

Dennis Maletich Junqueira

Simone Kashima

Sandra Coccuzzo Sampaio

Maria Carolina Elias

Marta Giovanetti

Carlos Alberto Scrideli

Svetoslav Nanev Slavov

Affiliations

Soon will be listed here.

Abstract

Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.

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