Comparative Clinical and Radiographic Success Rate of Bioceramic Premix Vs Biosilicate-based Medicament As Indirect Pulp Treatment Materials in Primary Molars: A Double-blind Randomized Trial with a Follow-up of 12 Months

Overview

Journal Int J Clin Pediatr Dent

Specialty Pediatrics

Date 2024 Oct 7

PMID 39372535

Authors

Payal Kothari

Aditi Mathur

Sunnypriyatham Tirupathi

Rashmi Chauhan

Meenakshi Nankar

Ashrita Suvarna

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate and compare the clinical and radiographic success of NeoPUTTY® and Biodentine™ as indirect pulp treatment (IPT) materials in primary molars.

Materials And Methods: This clinical trial was conducted on children aged 5-9 years. Class I carious lesions in primary molars indicated for IPT were divided into two groups-group I, NeoPUTTY®, and group II, Biodentine™. IPC was performed as per the standard protocols. The treated teeth were evaluated for clinical and radiographic success, along with the presence of a dentinal bridge at 6 and 12 months, by three blind examiners independently. All the data were tabulated, and statistical analysis was performed using the Mann-Whitney test.

Results: Interexaminer reliability was analyzed using Fleiss κ statistics, and it showed "good" agreement. Clinical success was 100% in both groups at 6- and 12-month follow-up, while radiographic success was also 100% at 6-month follow-up for both groups. However, at 12-month follow-up, it was 93.33% for group I and 100% for group II. The difference was statistically nonsignificant. The presence of a dentinal bridge at 12-month follow-up was seen in 86.66% of cases in group I and 100% of cases in group II, but there was no statistical difference observed between them with a -value of 0.555.

Conclusion: Within the limitations of the study, we conclude that NeoPUTTY® and Biodentine™ are equally effective as IPT agents in primary teeth.

How To Cite This Article: Kothari P, Mathur A, Tirupathi S, Comparative Clinical and Radiographic Success Rate of Bioceramic Premix vs Biosilicate-based Medicament as Indirect Pulp Treatment Materials in Primary Molars: A Double-blind Randomized Trial with a Follow-up of 12 Months. Int J Clin Pediatr Dent 2024;17(7):748-753.

References

Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A . Stem cell properties of human dental pulp stem cells. J Dent Res. 2002; 81(8):531-5. DOI: 10.1177/154405910208100806. View

McComb D . Caries-detector dyes--how accurate and useful are they?. J Can Dent Assoc. 2000; 66(4):195-8. View

Pinto A, de Araujo F, Franzon R, Cancado Figueiredo M, Henz S, Garcia-Godoy F . Clinical and microbiological effect of calcium hydroxide protection in indirect pulp capping in primary teeth. Am J Dent. 2007; 19(6):382-6. View

Sun Q, Gustin J, Tian F, Sidow S, Bergeron B, Ma J . Effects of pre-mixed hydraulic calcium silicate putties on osteogenic differentiation of human dental pulp stem cells in vitro. J Dent. 2021; 108:103653. DOI: 10.1016/j.jdent.2021.103653. View

Chauhan A, Dua P, Saini S, Mangla R, Butail A, Ahluwalia S . Outcomes of Indirect Pulp Treatment in Primary Posterior Teeth: 6 Months' Follow-up. Contemp Clin Dent. 2018; 9(Suppl 1):S69-S73. PMC: 6006903. DOI: 10.4103/ccd.ccd_48_18. View

George V, Janardhanan S, Varma B, Kumaran P, Xavier A . Clinical and radiographic evaluation of indirect pulp treatment with MTA and calcium hydroxide in primary teeth (in-vivo study). J Indian Soc Pedod Prev Dent. 2015; 33(2):104-10. DOI: 10.4103/0970-4388.155118. View

Coll J, Seale N, Vargas K, Marghalani A, Al Shamali S, Graham L . Primary Tooth Vital Pulp Therapy: A Systematic Review and Meta-analysis. Pediatr Dent. 2017; 39(1):16-123. View

Tziafa C, Koliniotou-Koumpia E, Papadimitriou S, Tziafas D . Dentinogenic responses after direct pulp capping of miniature swine teeth with Biodentine. J Endod. 2014; 40(12):1967-71. DOI: 10.1016/j.joen.2014.07.021. View

Boddeda K, Rani C, V Vanga N, Chandrabhatla S . Comparative evaluation of biodentine, 2% chlorhexidine with RMGIC and calcium hydroxide as indirect pulp capping materials in primary molars: An study. J Indian Soc Pedod Prev Dent. 2019; 37(1):60-66. DOI: 10.4103/JISPPD.JISPPD_213_17. View

10.

Miura M, Gronthos S, Zhao M, Lu B, Fisher L, Robey P . SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003; 100(10):5807-12. PMC: 156282. DOI: 10.1073/pnas.0937635100. View

11.

Casagrande L, Bento L, Dalpian D, Garcia-Godoy F, de Araujo F . Indirect pulp treatment in primary teeth: 4-year results. Am J Dent. 2010; 23(1):34-8. View

12.

Franzon R, Casagrande L, Pinto A, Garcia-Godoy F, Maltz M, de Araujo F . Clinical and radiographic evaluation of indirect pulp treatment in primary molars: 36 months follow-up. Am J Dent. 2007; 20(3):189-92. View

13.

Kim J, Song Y, Min K, Kim S, Koh J, Lee B . Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry. Restor Dent Endod. 2016; 41(1):29-36. PMC: 4751204. DOI: 10.5395/rde.2016.41.1.29. View

14.

Marchi J, Froner A, Alves H, Bergmann C, Araujo F . Analysis of primary tooth dentin after indirect pulp capping. J Dent Child (Chic). 2008; 75(3):295-300. View

15.

Falster C, Araujo F, Straffon L, Nor J . Indirect pulp treatment: in vivo outcomes of an adhesive resin system vs calcium hydroxide for protection of the dentin-pulp complex. Pediatr Dent. 2002; 24(3):241-8. View

16.

Sahin N, Saygili S, Akcay M . Clinical, radiographic, and histological evaluation of three different pulp-capping materials in indirect pulp treatment of primary teeth: a randomized clinical trial. Clin Oral Investig. 2021; 25(6):3945-3955. DOI: 10.1007/s00784-020-03724-4. View

17.

Mathur V, Dhillon J, Logani A, Kalra G . Evaluation of indirect pulp capping using three different materials: A randomized control trial using cone-beam computed tomography. Indian J Dent Res. 2017; 27(6):623-629. DOI: 10.4103/0970-9290.199588. View

18.

Rajasekharan S, Martens L, Cauwels R, Anthonappa R . Biodentine™ material characteristics and clinical applications: a 3 year literature review and update. Eur Arch Paediatr Dent. 2018; 19(1):1-22. DOI: 10.1007/s40368-018-0328-x. View

19.

Peng W, Liu W, Zhai W, Jiang L, Li L, Chang J . Effect of tricalcium silicate on the proliferation and odontogenic differentiation of human dental pulp cells. J Endod. 2011; 37(9):1240-6. DOI: 10.1016/j.joen.2011.05.035. View

20.

Kaul S, Kumar A, Jasrotia A, Gorkha K, Kumari S, Jeri S . Comparative Analysis of Biodentine, Calcium Hydroxide, and 2% Chlorhexidine with Resin-modified Glass Ionomer Cement as Indirect Pulp Capping Materials in Young Permanent Molars. J Contemp Dent Pract. 2021; 22(5):511-516. View