Association Between Serum Level of Uric Acid in Japanese Young Patients with Coronary Spastic Angina Receiving Coronary Angiography

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 2024 Oct 5

PMID 39368018

Authors

Kota Tanazawa

Hidefumi Akioka

Kunio Yufu

Taiki Makita

Hiroki Sato

Yuki Iwabuchi

Yuma Ono

Hirochika Yamasaki

Masaki Takahashi

Naoko Ogawa

Taisuke Harada

Kazuki Mitarai

Nozomi Kodama

Shuichiro Yamauchi

Masayuki Takano

Kei Hirota

Miho Miyoshi

Keisuke Yonezu

Katsunori Tawara

Ichitaro Abe

Hidekazu Kondo

Shotaro Saito

Akira Fukui

Tomoko Fukuda

Tetsuji Shinohara

Kumiko Akiyoshi

Yasushi Teshima

Naohiko Takahashi

Affiliations

Soon will be listed here.

Abstract

Endothelial dysfunction may trigger coronary spastic angina (CSA). However, the risk factors for CSA in young patients remain unclear. This study aimed to investigate the age-dependent role of serum uric acid levels in patients with CSA. We enrolled 423 patients who underwent an ergonovine tolerance test during coronary angiography for the CSA evaluation. We categorized the patients as (1) young (age ≤ 65 years) CSA-positive (n = 33), (2) young CSA-negative (n = 138), (3) elderly (age > 66 years) CSA-positive (n = 42), and (4) elderly CSA-negative (n = 210) groups. In the young groups, the smoker proportion (57.6 vs. 38.4%, p = 0.04) and serum uric acid levels (6.3 ± 1.4 vs. 5.4 ± 1.5 mg/dl, p = 0.006) were significantly higher in the CSA-positive compared with the CSA-negative group. Conversely, in the elderly group, the male proportion (66.6 vs. 47.1%, p = 0.02) and alcohol consumption level (40.5 vs. 21.0%, p = 0.01) were significantly higher in the CSA-positive compared with the CSA-negative group. The multivariate analysis in young groups revealed the independent association between the serum uric acid level (p = 0.02) and the presence of CSA. Our results indicate that elevated serum uric acid levels may affect CSA development in young patients.

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