Significance of Research on Natural Products from Marine-derived Species As a Source Against Pathogenic Bacteria

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Oct 4

PMID 39364162

Authors

Bin Wang

Jin Cai

Longtao Huang

Yonghao Chen

Ruoxi Wang

Mengyao Luo

Meng Yang

Mohan Zhang

Nasihat

Guangying Chen

Guolei Huang

Caijuan Zheng

Affiliations

Soon will be listed here.

Abstract

Bacterial infections pose a significant clinical burden on global health. The growing incidence of drug-resistant pathogens highlights the critical necessity to identify and isolate bioactive compounds from marine resources. Marine-derived fungi could provide novel lead compounds against pathogenic bacteria. Due to the particularity of the marine environment, species derived from marine sources have proven to be potent producers of bioactive secondary metabolites and have played a considerable role in advancing drug development. This study reviews the structural diversity and activities against pathogenic bacteria of secondary metabolites isolated from marine-derived species over the past 14 years (January 2010-June 2024), and 337 natural products (including 145 new compounds) were described. The structures were divided into five major categories-terpenoids, nitrogen-containing compounds, polyketides, steroids, and other classes. These antimicrobial metabolites will offer lead compounds to the development and innovation of antimicrobial agents.

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