Microbial Upcycling of Depolymerized Lignin into Value-Added Chemicals

Overview

Journal Biodes Res

Date 2024 Oct 4

PMID 39364043

Authors

Yang Zhang

Cheng Cheng

Bixia Fu

Teng Long

Ning He

Jianqiang Fan

Zheyong Xue

Anqi Chen

Jifeng Yuan

Affiliations

Soon will be listed here.

Abstract

Lignin is one of the most widespread organic compounds found on earth, boasting a wealth of aromatic molecules. The use of lignin feedstock for biochemical productions is of great importance for achieving "carbon neutrality." In recent years, a strategy for lignin valorization known as the "bio-funnel" has been proposed as a means to generate a variety of commercially valuable chemicals from lignin-derived compounds. The implementation of biocatalysis and metabolic engineering techniques has substantially advanced the biotransformation of depolymerized lignin into chemicals and materials within the supply chain. In this review, we present an overview of the latest advancements in microbial upcycling of depolymerized lignin into value-added chemicals. Besides, the review provides insights into the problems facing current biological lignin valorization while proposing further research directions to improve these technologies for the extensive accomplishment of the lignin upcycling.

References

Yang W, Tang H, Ni J, Wu Q, Hua D, Tao F . Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin. PLoS One. 2013; 8(6):e67339. PMC: 3696112. DOI: 10.1371/journal.pone.0067339. View

Manfrao-Netto J, Lund F, Muratovska N, Larsson E, Skorupa Parachin N, Carlquist M . Metabolic engineering of Pseudomonas putida for production of vanillylamine from lignin-derived substrates. Microb Biotechnol. 2021; 14(6):2448-2462. PMC: 8601178. DOI: 10.1111/1751-7915.13764. View

Barton N, Horbal L, Starck S, Kohlstedt M, Luzhetskyy A, Wittmann C . Enabling the valorization of guaiacol-based lignin: Integrated chemical and biochemical production of cis,cis-muconic acid using metabolically engineered Amycolatopsis sp ATCC 39116. Metab Eng. 2017; 45:200-210. DOI: 10.1016/j.ymben.2017.12.001. View

Austin S, Kontur W, Ulbrich A, Oshlag J, Zhang W, Higbee A . Metabolism of Multiple Aromatic Compounds in Corn Stover Hydrolysate by Rhodopseudomonas palustris. Environ Sci Technol. 2015; 49(14):8914-22. PMC: 5031247. DOI: 10.1021/acs.est.5b02062. View

Yang S, Shim G, Kim B, Ahn J . Biological synthesis of coumarins in Escherichia coli. Microb Cell Fact. 2015; 14:65. PMC: 4419511. DOI: 10.1186/s12934-015-0248-y. View

Spence E, Calvo-Bado L, Mines P, Bugg T . Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin. Microb Cell Fact. 2021; 20(1):15. PMC: 7814577. DOI: 10.1186/s12934-020-01504-z. View

Zhou H, Guo W, Xu B, Teng Z, Tao D, Lou Y . Screening and identification of lignin-degrading bacteria in termite gut and the construction of LiP-expressing recombinant Lactococcus lactis. Microb Pathog. 2017; 112:63-69. DOI: 10.1016/j.micpath.2017.09.047. View

Ma J, Zhang K, Liao H, Hector S, Shi X, Li J . Genomic and secretomic insight into lignocellulolytic system of an endophytic bacterium Pantoea ananatis Sd-1. Biotechnol Biofuels. 2016; 9:25. PMC: 4736469. DOI: 10.1186/s13068-016-0439-8. View

Xiong X, Liao H, Ma J, Liu X, Zhang L, Shi X . Isolation of a rice endophytic bacterium, Pantoea sp. Sd-1, with ligninolytic activity and characterization of its rice straw degradation ability. Lett Appl Microbiol. 2013; 58(2):123-9. DOI: 10.1111/lam.12163. View

10.

Moraes E, Alvarez T, Persinoti G, Tomazetto G, Brenelli L, Paixao D . Lignolytic-consortium omics analyses reveal novel genomes and pathways involved in lignin modification and valorization. Biotechnol Biofuels. 2018; 11:75. PMC: 5863372. DOI: 10.1186/s13068-018-1073-4. View

11.

Tuck C, Perez E, Horvath I, Sheldon R, Poliakoff M . Valorization of biomass: deriving more value from waste. Science. 2012; 337(6095):695-9. DOI: 10.1126/science.1218930. View

12.

Eschrich K, van der Bolt F, de Kok A, van Berkel W . Role of Tyr201 and Tyr385 in substrate activation by p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Eur J Biochem. 1993; 216(1):137-46. DOI: 10.1111/j.1432-1033.1993.tb18125.x. View

13.

Fu B, Xiao G, Zhang Y, Yuan J . One-Pot Bioconversion of Lignin-Derived Substrates into Gallic Acid. J Agric Food Chem. 2021; 69(38):11336-11341. DOI: 10.1021/acs.jafc.1c03960. View

14.

Chen Y, Chai L, Zhu Y, Yang Z, Zheng Y, Zhang H . Biodegradation of kraft lignin by a bacterial strain Comamonas sp. B-9 isolated from eroded bamboo slips. J Appl Microbiol. 2012; 112(5):900-6. DOI: 10.1111/j.1365-2672.2012.05275.x. View

15.

Sana B, Chia K, Raghavan S, Ramalingam B, Nagarajan N, Seayad J . Development of a genetically programed vanillin-sensing bacterium for high-throughput screening of lignin-degrading enzyme libraries. Biotechnol Biofuels. 2017; 10:32. PMC: 5291986. DOI: 10.1186/s13068-017-0720-5. View

16.

Singhvi M, Kim B . Lignin valorization using biological approach. Biotechnol Appl Biochem. 2020; 68(3):459-468. DOI: 10.1002/bab.1995. View

17.

Suzuki Y, Otsuka Y, Araki T, Kamimura N, Masai E, Nakamura M . Lignin valorization through efficient microbial production of β-ketoadipate from industrial black liquor. Bioresour Technol. 2021; 337:125489. DOI: 10.1016/j.biortech.2021.125489. View

18.

Tian J, Pourcher A, Bouchez T, Gelhaye E, Peu P . Occurrence of lignin degradation genotypes and phenotypes among prokaryotes. Appl Microbiol Biotechnol. 2014; 98(23):9527-44. DOI: 10.1007/s00253-014-6142-4. View

19.

Ni J, Wu Y, Tao F, Peng Y, Xu P . A Coenzyme-Free Biocatalyst for the Value-Added Utilization of Lignin-Derived Aromatics. J Am Chem Soc. 2018; 140(47):16001-16005. DOI: 10.1021/jacs.8b08177. View

20.

Sonoki T, Morooka M, Sakamoto K, Otsuka Y, Nakamura M, Jellison J . Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds. J Biotechnol. 2014; 192 Pt A:71-7. DOI: 10.1016/j.jbiotec.2014.10.027. View