Genomic Analysis of an Acute Gastroenteritis Outbreak Caused by Rotavirus C in Hebei, China

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2024 Oct 2

PMID 39358760

Authors

Kaiying Wang

Yun Wang

Lang Yang

Jinhui Li

Peihan Li

Chaojie Yang

Leili Jia

Shaofu Qiu

Hongbin Song

Peng Li

Affiliations

Soon will be listed here.

Abstract

Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.

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