Biomaterials for Reliable Wearable Health Monitoring: Applications in Skin and Eye Integration

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2024 Oct 2

PMID 39357154

Authors

Seokkyoon Hong

Tianhao Yu

Ziheng Wang

Chi Hwan Lee

Affiliations

Soon will be listed here.

Abstract

Recent advancements in biomaterials have significantly impacted wearable health monitoring, creating opportunities for personalized and non-invasive health assessments. These developments address the growing demand for customized healthcare solutions. Durability is a critical factor for biomaterials in wearable applications, as they must withstand diverse wearing conditions effectively. Therefore, there is a heightened focus on developing biomaterials that maintain robust and stable functionalities, essential for advancing wearable sensing technologies. This review examines the biomaterials used in wearable sensors, specifically those interfaced with human skin and eyes, highlighting essential strategies for achieving long-lasting and stable performance. We specifically discuss three main categories of biomaterials-hydrogels, fibers, and hybrid materials-each offering distinct properties ideal for use in durable wearable health monitoring systems. Moreover, we delve into the latest advancements in biomaterial-based sensors, which hold the potential to facilitate early disease detection, preventative interventions, and tailored healthcare approaches. We also address ongoing challenges and suggest future directions for research on material-based wearable sensors to encourage continuous innovation in this dynamic field.

References

Choi H, Yi J, Cho S, Hahn S . Multifunctional micro/nanomotors as an emerging platform for smart healthcare applications. Biomaterials. 2021; 279:121201. DOI: 10.1016/j.biomaterials.2021.121201. View

Zheng C, Zheng A, Liu B, Zhang X, He Y, Li J . One-pot synthesized DNA-templated Ag/Pt bimetallic nanoclusters as peroxidase mimics for colorimetric detection of thrombin. Chem Commun (Camb). 2014; 50(86):13103-6. DOI: 10.1039/c4cc05339g. View

Ye M, Zhu Y, Lu Y, Gan L, Zhang Y, Zhao Y . Magnetic nanomaterials with unique nanozymes-like characteristics for colorimetric sensors: A review. Talanta. 2021; 230:122299. DOI: 10.1016/j.talanta.2021.122299. View

Liu H, Wang X, Cao Y, Yang Y, Yang Y, Gao Y . Freezing-Tolerant, Highly Sensitive Strain and Pressure Sensors Assembled from Ionic Conductive Hydrogels with Dynamic Cross-Links. ACS Appl Mater Interfaces. 2020; 12(22):25334-25344. DOI: 10.1021/acsami.0c06067. View

Owyeung R, Panzer M, Sonkusale S . Colorimetric Gas Sensing Washable Threads for Smart Textiles. Sci Rep. 2019; 9(1):5607. PMC: 6449334. DOI: 10.1038/s41598-019-42054-8. View

Rickert C, Wittmann B, Fromme R, Lieleg O . Highly Transparent Covalent Mucin Coatings Improve the Wettability and Tribology of Hydrophobic Contact Lenses. ACS Appl Mater Interfaces. 2020; 12(25):28024-28033. DOI: 10.1021/acsami.0c06847. View

Zhao X, Chen F, Li Y, Lu H, Zhang N, Ma M . Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment. Nat Commun. 2018; 9(1):3579. PMC: 6123392. DOI: 10.1038/s41467-018-05904-z. View

Choi H, Shin D, Yang J, Lee S, Figueiredo C, Sinopoli S . Smart textile lighting/display system with multifunctional fibre devices for large scale smart home and IoT applications. Nat Commun. 2022; 13(1):814. PMC: 8831553. DOI: 10.1038/s41467-022-28459-6. View

Fan W, Liu T, Wu F, Wang S, Ge S, Li Y . An Antisweat Interference and Highly Sensitive Temperature Sensor Based on Poly(3,4-ethylenedioxythiophene)-Poly(styrenesulfonate) Fiber Coated with Polyurethane/Graphene for Real-Time Monitoring of Body Temperature. ACS Nano. 2023; 17(21):21073-21082. PMC: 10655239. DOI: 10.1021/acsnano.3c04246. View

10.

Zhu D, Liu B, Wei G . Two-Dimensional Material-Based Colorimetric Biosensors: A Review. Biosensors (Basel). 2021; 11(8). PMC: 8392748. DOI: 10.3390/bios11080259. View

11.

Yoo J, Oh S, Shalish W, Maeng W, Cerier E, Jeanne E . Wireless broadband acousto-mechanical sensing system for continuous physiological monitoring. Nat Med. 2023; 29(12):3137-3148. DOI: 10.1038/s41591-023-02637-5. View

12.

Li J, Xia B, Xiao X, Huang Z, Yin J, Jiang Y . Stretchable Thermoelectric Fibers with Three-Dimensional Interconnected Porous Network for Low-Grade Body Heat Energy Harvesting. ACS Nano. 2023; 17(19):19232-19241. DOI: 10.1021/acsnano.3c05797. View

13.

Yang Y, Wei X, Zhang N, Zheng J, Chen X, Wen Q . A non-printed integrated-circuit textile for wireless theranostics. Nat Commun. 2021; 12(1):4876. PMC: 8361012. DOI: 10.1038/s41467-021-25075-8. View

14.

Zhang C, Hsieh M, Wu S, Li S, Wu J, Liu S . A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function. Biomaterials. 2019; 231:119672. DOI: 10.1016/j.biomaterials.2019.119672. View

15.

Gao Y, Yu L, Yeo J, Lim C . Flexible Hybrid Sensors for Health Monitoring: Materials and Mechanisms to Render Wearability. Adv Mater. 2019; 32(15):e1902133. DOI: 10.1002/adma.201902133. View

16.

Kim T, Hong S, Jeong S, Bae H, Cheong S, Choi H . Multifunctional Intelligent Wearable Devices Using Logical Circuits of Monolithic Gold Nanowires. Adv Mater. 2023; 35(45):e2303401. DOI: 10.1002/adma.202303401. View

17.

Su X, Wang H, Tian Z, Duan X, Chai Z, Feng Y . A Solvent Co-cross-linked Organogel with Fast Self-Healing Capability and Reversible Adhesiveness at Extreme Temperatures. ACS Appl Mater Interfaces. 2020; 12(26):29757-29766. DOI: 10.1021/acsami.0c04933. View

18.

Yan W, Noel G, Loke G, Meiklejohn E, Khudiyev T, Marion J . Single fibre enables acoustic fabrics via nanometre-scale vibrations. Nature. 2022; 603(7902):616-623. DOI: 10.1038/s41586-022-04476-9. View

19.

Hong S, Zhang H, Lee J, Yu T, Cho S, Park T . Spongy Ag Foam for Soft and Stretchable Strain Gauges. ACS Appl Mater Interfaces. 2024; 16(20):26613-26623. DOI: 10.1021/acsami.4c04719. View

20.

Kim J, Campbell A, de Avila B, Wang J . Wearable biosensors for healthcare monitoring. Nat Biotechnol. 2019; 37(4):389-406. PMC: 8183422. DOI: 10.1038/s41587-019-0045-y. View