Hepatitis C Virus Infection and Parkinson's Disease: Insights from a Joint Sex-stratified BioOptimatics Meta-analysis

Overview

Journal Sci Rep

Specialty Science

Date 2024 Oct 1

PMID 39354018

Authors

Isis Narvaez-Bandera

Deiver Suarez-Gomez

Coral Del Mar Castro-Rivera

Alaina Camasta-Beniquez

Morelia Duran-Quintana

Mauricio Cabrera-Rios

Clara E Isaza

Affiliations

Soon will be listed here.

Abstract

Hepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson's disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology. HCV infection and PD have been previously suggested to be related. This work aimed to identify potential biomarkers and pathways that may play a role in the joint development of PD and HCV infection. Using BioOptimatics-bioinformatics driven by mathematical global optimization-, 22 publicly available microarray and RNAseq datasets for both diseases were analyzed, focusing on sex-specific differences. Our results revealed that 19 genes, including MT1H, MYOM2, and RPL18, exhibited significant changes in expression in both diseases. Pathway and network analyses stratified by sex indicated that these gene expression changes were enriched in processes related to immune response regulation in females and immune cell activation in males. These findings suggest a potential link between HCV infection and PD, highlighting the importance of further investigation into the underlying mechanisms and potential therapeutic targets involved.

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