Accelerated Bone Loss in Late Reproductive-aged and Perimenopausal Women with Vitamin D Insufficiency

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2024 Sep 30

PMID 39349871

Authors

Min-Jeong Kim

Sunmie Kim

Jin Ju Kim

Kyung Hee Han

Affiliations

Soon will be listed here.

Abstract

Introduction: The association between serum vitamin D levels and bone mineral density (BMD) varies by race and gender. This study aimed to evaluate this relationship between serum vitamin D levels and BMD, and changes of BMD over time in Korean women.

Materials And Methods: We analyzed data from 586 generally healthy Korean women aged 29-79 who underwent health check-ups at Seoul National University Gangnam Center between 2010 and 2011 (baseline measurement) and 2015-2016 (follow-up). Dual energy X-ray absorptiometry (DEXA) and serum 25-hydroxyvitamin D (25OH-D) level measurements were conducted. We assessed the association between serum 25OH-D levels and BMD, as well as changes in BMD over time.

Results: The mean age of participants was 51.3 ± 7.9 years, with a mean follow-up interval of 4.6 ± 0.7 years, and mean serum 25OH-D level of 20.6 ± 8.5 ng/ml. Baseline serum 25OH-D levels did not correlate with BMD values at the lumbar spine, femoral neck, or total femur, nor with changes in BMD over time. A significant negative association was found between perimenopausal status and BMD changes at all sites, and between premenopausal status and lumbar bone mass, compared to postmenopausal status in the 25OH-D < 20 ng/ml group. This association was not observed in women with higher serum 25OH-D levels.

Conclusions: Serum 25OH-D levels did not correlate with BMD levels or changes in BMD overall. However, in late reproductive-aged and perimenopausal women with serum 25OH-D insufficiency, there was a significant association with accelerated bone loss.

References

Brenneman S, Barrett-Connor E, Sajjan S, Markson L, Siris E . Impact of recent fracture on health-related quality of life in postmenopausal women. J Bone Miner Res. 2006; 21(6):809-16. DOI: 10.1359/jbmr.060301. View

Amin S, Achenbach S, Atkinson E, Khosla S, Melton 3rd L . Trends in fracture incidence: a population-based study over 20 years. J Bone Miner Res. 2013; 29(3):581-9. PMC: 3929546. DOI: 10.1002/jbmr.2072. View

Ahn S, Park S, Park S, Yoo J, Jung H, Nho J . Osteoporosis and Osteoporotic Fracture Fact Sheet in Korea. J Bone Metab. 2020; 27(4):281-290. PMC: 7746478. DOI: 10.11005/jbm.2020.27.4.281. View

Holick M, Chen T . Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87(4):1080S-6S. DOI: 10.1093/ajcn/87.4.1080S. View

van Schoor N, Visser M, Pluijm S, Kuchuk N, Smit J, Lips P . Vitamin D deficiency as a risk factor for osteoporotic fractures. Bone. 2008; 42(2):260-6. DOI: 10.1016/j.bone.2007.11.002. View

Yu H, Kwon M, Woo H, Park H . Analysis of 25-Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation. J Clin Lab Anal. 2016; 30(6):905-911. PMC: 6807230. DOI: 10.1002/jcla.21955. View

Zhang S, Miller D, Li W . Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System. Int J Mol Sci. 2021; 22(4). PMC: 7924658. DOI: 10.3390/ijms22042128. View

Wintermeyer E, Ihle C, Ehnert S, Stockle U, Ochs G, de Zwart P . Crucial Role of Vitamin D in the Musculoskeletal System. Nutrients. 2016; 8(6). PMC: 4924160. DOI: 10.3390/nu8060319. View

Man P, van der Meer I, Lips P, Middelkoop B . Vitamin D status and bone mineral density in the Chinese population: a review. Arch Osteoporos. 2016; 11:14. PMC: 4819723. DOI: 10.1007/s11657-016-0265-4. View

10.

van Ballegooijen A, Robinson-Cohen C, Katz R, Criqui M, Budoff M, Li D . Vitamin D metabolites and bone mineral density: The multi-ethnic study of atherosclerosis. Bone. 2015; 78:186-93. PMC: 4466133. DOI: 10.1016/j.bone.2015.05.008. View

11.

Wei Q, Chen Z, Tan X, Su H, Chen X, He W . Relation of Age, Sex and Bone Mineral Density to Serum 25-Hydroxyvitamin D Levels in Chinese Women and Men. Orthop Surg. 2016; 7(4):343-9. PMC: 6583757. DOI: 10.1111/os.12206. View

12.

Wang D, Yang Y . The Relationship Between Serum 25-Hydroxyvitamin D Levels and Osteoporosis in Postmenopausal Women. Clin Interv Aging. 2023; 18:619-627. PMC: 10122466. DOI: 10.2147/CIA.S405317. View

13.

Gutierrez O, Farwell W, Kermah D, Taylor E . Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey. Osteoporos Int. 2010; 22(6):1745-53. PMC: 3093445. DOI: 10.1007/s00198-010-1383-2. View

14.

Joo N, Dawson-Hughes B, Kim Y, Oh K, Yeum K . Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-3, 2009 and KNHANES V-1, 2010). J Bone Miner Res. 2012; 28(4):764-70. DOI: 10.1002/jbmr.1790. View

15.

Joo N, Dawson-Hughes B, Yeum K . 25-Hydroxyvitamin D, calcium intake, and bone mineral content in adolescents and young adults: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-2, 3, 2008-2009 and V-1, 2010). J Clin Endocrinol Metab. 2013; 98(9):3627-36. DOI: 10.1210/jc.2013-1480. View

16.

Yoo K, Kim M, Ly S . Association between vitamin D intake and bone mineral density in Koreans aged ≥ 50 years: analysis of the 2009 Korea National Health and Nutrition Examination Survey using a newly established vitamin D database. Nutr Res Pract. 2019; 13(2):115-125. PMC: 6449542. DOI: 10.4162/nrp.2019.13.2.115. View

17.

You H, Shin H, Song S, Ly S . Vitamin D intake and bone mineral density in Korean adults: analysis of the 2009-2011 Korea National Health and Nutrition Examination Survey. Nutr Res Pract. 2022; 16(6):775-788. PMC: 9702544. DOI: 10.4162/nrp.2022.16.6.775. View

18.

Soules M, Sherman S, Parrott E, Rebar R, Santoro N, Utian W . Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertil Steril. 2001; 76(5):874-8. DOI: 10.1016/s0015-0282(01)02909-0. View

19.

Deluca H . Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80(6 Suppl):1689S-96S. DOI: 10.1093/ajcn/80.6.1689S. View

20.

Holick M . Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2008; 19(2):73-8. PMC: 2665033. DOI: 10.1016/j.annepidem.2007.12.001. View