Ultrafast Nuclear Magnetic Resonance As a Tool to Detect Rapid Chemical Change in Solution

Overview

Journal ACS Phys Chem Au

Publisher American Chemical Society

Specialty Chemistry

Date 2024 Sep 30

PMID 39346603

Authors

Ben J Tickner

Kawarpal Singh

Vladimir V Zhivonitko

Ville-Veikko Telkki

Affiliations

Soon will be listed here.

Abstract

Ultrafast nuclear magnetic resonance (NMR) uses spatial encoding to record an entire two-dimensional data set in just a single scan. The approach can be applied to either Fourier-transform or Laplace-transform NMR. In both cases, acquisition times are significantly shorter than traditional 2D/Laplace NMR experiments, which allows them to be used to monitor rapid chemical transformations. This Perspective outlines the principles of ultrafast NMR and focuses on examples of its use to detect fast molecular conversions with high temporal resolution. We discuss how this valuable tool can be applied in the future to study a much wider variety of novel reactivity.

References

Keshari K, Wilson D . Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev. 2013; 43(5):1627-59. PMC: 4086923. DOI: 10.1039/c3cs60124b. View

Zhang G, Ahola S, Lerche M, Telkki V, Hilty C . Identification of Intracellular and Extracellular Metabolites in Cancer Cells Using C Hyperpolarized Ultrafast Laplace NMR. Anal Chem. 2018; 90(18):11131-11137. PMC: 6168181. DOI: 10.1021/acs.analchem.8b03096. View

McVeigh E, Yang A, Zerhouni E . Rapid measurement of T1 with spatially selective pre-inversion pulses. Med Phys. 1990; 17(1):131-4. PMC: 2041915. DOI: 10.1118/1.596543. View

Boisseau R, Bussy U, Giraudeau P, Boujtita M . In situ ultrafast 2D NMR spectroelectrochemistry for real-time monitoring of redox reactions. Anal Chem. 2014; 87(1):372-5. DOI: 10.1021/ac5041956. View

Kupce E, Freeman R . Fast multi-dimensional Hadamard spectroscopy. J Magn Reson. 2003; 163(1):56-63. DOI: 10.1016/s1090-7807(03)00036-3. View

Herrera A, Fernandez-Valle E, Gutierrez E, Martinez-Alvarez R, Molero D, Pardo Z . 2D ultrafast HMBC: a valuable tool for monitoring organic reactions. Org Lett. 2009; 12(1):144-7. DOI: 10.1021/ol902532f. View

Boutin C, Leonce E, Brotin T, Jerschow A, Berthault P . Ultrafast Z-Spectroscopy for Xe NMR-Based Sensors. J Phys Chem Lett. 2014; 4(23):4172-4176. PMC: 3927827. DOI: 10.1021/jz402261h. View

Loening N, Keeler J, Morris G . One-dimensional DOSY. J Magn Reson. 2001; 153(1):103-12. DOI: 10.1006/jmre.2001.2423. View

Kharbanda Y, Mailhiot S, Mankinen O, Urbanczyk M, Telkki V . Monitoring cheese ripening by single-sided nuclear magnetic resonance. J Dairy Sci. 2023; 106(3):1586-1595. PMC: 9947740. DOI: 10.3168/jds.2022-22458. View

10.

Ben-Eliezer N, Irani M, Frydman L . Super-resolved spatially encoded single-scan 2D MRI. Magn Reson Med. 2010; 63(6):1594-600. DOI: 10.1002/mrm.22377. View

11.

Grazia Concilio M, Jacquemmoz C, Boyarskaya D, Masson G, Dumez J . Ultrafast Maximum-Quantum NMR Spectroscopy for the Analysis of Aromatic Mixtures. Chemphyschem. 2018; . DOI: 10.1002/cphc.201800667. View

12.

Praud C, Ribay V, Dey A, Charrier B, Mandral J, Farjon J . Optimization of heteronuclear ultrafast 2D NMR for the study of complex mixtures hyperpolarized by dynamic nuclear polarization. Anal Methods. 2023; 15(45):6209-6219. DOI: 10.1039/d3ay01681a. View

13.

Javed M, Ahola S, Hakansson P, Mankinen O, Aslam M, Filippov A . Structure and dynamics elucidation of ionic liquids using multidimensional Laplace NMR. Chem Commun (Camb). 2017; 53(80):11056-11059. DOI: 10.1039/c7cc05493a. View

14.

Palmer M, Suiter C, Henry G, Rovnyak J, Hoch J, Polenova T . Sensitivity of nonuniform sampling NMR. J Phys Chem B. 2015; 119(22):6502-15. PMC: 4857715. DOI: 10.1021/jp5126415. View

15.

Andre M, Piotto M, Caldarelli S, Dumez J . Ultrafast high-resolution magic-angle-spinning NMR spectroscopy. Analyst. 2015; 140(12):3942-6. DOI: 10.1039/c5an00653h. View

16.

Schanda P, Forge V, Brutscher B . Protein folding and unfolding studied at atomic resolution by fast two-dimensional NMR spectroscopy. Proc Natl Acad Sci U S A. 2007; 104(27):11257-62. PMC: 2040886. DOI: 10.1073/pnas.0702069104. View

17.

Angelovski G, Tickner B, Wang G . Opportunities and challenges with hyperpolarized bioresponsive probes for functional imaging using magnetic resonance. Nat Chem. 2023; 15(6):755-763. DOI: 10.1038/s41557-023-01211-3. View

18.

Loening N, Thrippleton M, Keeler J, Griffin R . Single-scan longitudinal relaxation measurements in high-resolution NMR spectroscopy. J Magn Reson. 2003; 164(2):321-8. DOI: 10.1016/s1090-7807(03)00186-1. View

19.

Tal A, Frydman L . Single-scan multidimensional magnetic resonance. Prog Nucl Magn Reson Spectrosc. 2010; 57(3):241-92. DOI: 10.1016/j.pnmrs.2010.04.001. View

20.

Pardo Z, Olsen G, Fernandez-Valle M, Frydman L, Martinez-Alvarez R, Herrera A . Monitoring mechanistic details in the synthesis of pyrimidines via real-time, ultrafast multidimensional NMR spectroscopy. J Am Chem Soc. 2012; 134(5):2706-15. PMC: 5040488. DOI: 10.1021/ja210154g. View