Association Between Metabolic Syndrome and Musculoskeletal Status: A Cross-Sectional Study of NHANES

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2024 Sep 30

PMID 39345904

Authors

Yue Shi

Shuhan Li

Xiaolong Xie

Yue Feng

Affiliations

Soon will be listed here.

Abstract

Objective: The metabolic effects of metabolic syndrome (MetS) on musculoskeletal metabolism are controversial. This study explored the effect of MetS on bone mineral density (BMD) and muscle quality index (MQI).

Methods: Data from the NHANES database from 2011 to 2014 were extracted, and nonpregnant participants aged 45-59 years were included. The included data were first weighted by complex sampling, and then, the effect of MetS on BMD and MQI was analyzed using multifactorial linear regression. We then performed a stratified analysis by gender and BMI classification. Moreover, a mediation analysis of MetS on BMD was conducted, with MQI as a mediating variable. A propensity score matching analysis method with a complex sampling design was additionally performed to verify the stability of the results.

Results: A total of 1943 participants were eventually included. After adjusting for covariates, the results of linear regression show that MetS is associated with elevated pelvic BMD (beta = 0.03; 95% CI = 0.01, 0.06; =0.02) and reduced MQI, especially arm MQI (beta = -1.02; 95% CI = -1.27, -0.77; < 0.0001). MetS is more associated with BMD in women, MQI in normal or heavyweight, and BMD in lightweight, according to stratified analysis. MQI explains the indirect effect of MetS on BMD (beta = 0.007; 95% CI = 0.003, 0.010).

Conclusion: This study provides evidence that MetS elevates BMD and reduces MQI, and further, that there is a mediating effect of MQI on elevated BMD.

Citing Articles

Etiology, Pathophysiology, and Treatment Strategies in the Prevention and Management of Metabolic Syndrome.

Patial R, Batta I, Thakur M, Sobti R, Agrawal D Arch Intern Med Res. 2024; 7(4):273-283.

PMID: 39574946 PMC: 11580789. DOI: 10.26502/aimr.0184.

References

Al-Hail N, Butler A, Dargham S, Abou Seif A, Atkin S . Creatine Kinase Is a Marker of Metabolic Syndrome in Qatari Women With and Without Polycystic Ovarian Syndrome. Front Endocrinol (Lausanne). 2019; 10:659. PMC: 6773810. DOI: 10.3389/fendo.2019.00659. View

Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D . Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012; 35(11):2402-11. PMC: 3476894. DOI: 10.2337/dc12-0336. View

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

Babagoli M, Soleimani M, Baghdadi S, Sheikh Vatan M, Shafiei S . Does metabolic syndrome increase the risk of fracture? A systematic review and meta-analysis. Arch Osteoporos. 2022; 17(1):118. DOI: 10.1007/s11657-022-01149-y. View

Salas R, Tijerina A, Cardona M, Bouzas C, Ramirez E, Martinez G . Association between Bone Mineral Density and Metabolic Syndrome among Reproductive, Menopausal Transition, and Postmenopausal Women. J Clin Med. 2021; 10(21). PMC: 8584545. DOI: 10.3390/jcm10214819. View

Szulc P, Varennes A, Delmas P, Goudable J, Chapurlat R . Men with metabolic syndrome have lower bone mineral density but lower fracture risk--the MINOS study. J Bone Miner Res. 2010; 25(6):1446-54. DOI: 10.1002/jbmr.13. View

Lopes L, Vaz-Goncalves L, Schincaglia R, Gonzalez M, Prado C, de Oliveira E . Sex and population-specific cutoff values of muscle quality index: Results from NHANES 2011-2014. Clin Nutr. 2022; 41(6):1328-1334. DOI: 10.1016/j.clnu.2022.04.026. View

Nishikawa H, Asai A, Fukunishi S, Nishiguchi S, Higuchi K . Metabolic Syndrome and Sarcopenia. Nutrients. 2021; 13(10). PMC: 8541622. DOI: 10.3390/nu13103519. View

Chang K, Yang K, Wu W, Huang K, Han D . Association between metabolic syndrome and limb muscle quantity and quality in older adults: a pilot ultrasound study. Diabetes Metab Syndr Obes. 2019; 12:1821-1830. PMC: 6750006. DOI: 10.2147/DMSO.S219649. View

10.

Zhou J, Zhang Q, Yuan X, Wang J, Li C, Sheng H . Association between metabolic syndrome and osteoporosis: a meta-analysis. Bone. 2013; 57(1):30-5. DOI: 10.1016/j.bone.2013.07.013. View

11.

Chen H, Zheng X, Zong X, Li Z, Li N, Hur J . Metabolic syndrome, metabolic comorbid conditions and risk of early-onset colorectal cancer. Gut. 2020; 70(6):1147-1154. PMC: 8032822. DOI: 10.1136/gutjnl-2020-321661. View

12.

Zhang M, Chen J, Yin Z, Wang L, Peng L . The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study. Transl Psychiatry. 2021; 11(1):633. PMC: 8668963. DOI: 10.1038/s41398-021-01759-z. View

13.

Saklayen M . The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018; 20(2):12. PMC: 5866840. DOI: 10.1007/s11906-018-0812-z. View

14.

Wani K, Yakout S, Ansari M, Sabico S, Hussain S, Alokail M . Metabolic Syndrome in Arab Adults with Low Bone Mineral Density. Nutrients. 2019; 11(6). PMC: 6627685. DOI: 10.3390/nu11061405. View

15.

Hofmeister F, Baber L, Ferrari U, Hintze S, Jarmusch S, Krause S . Late-onset neuromuscular disorders in the differential diagnosis of sarcopenia. BMC Neurol. 2021; 21(1):241. PMC: 8229316. DOI: 10.1186/s12883-021-02264-y. View

16.

Tanaka M, Okada H, Hashimoto Y, Kumagai M, Nishimura H, Oda Y . Relationship between metabolic syndrome and trunk muscle quality as well as quantity evaluated by computed tomography. Clin Nutr. 2019; 39(6):1818-1825. DOI: 10.1016/j.clnu.2019.07.021. View

17.

Loke S, Chang H, Li W . Association between metabolic syndrome and bone mineral density in a Taiwanese elderly population. J Bone Miner Metab. 2017; 36(2):200-208. DOI: 10.1007/s00774-017-0826-7. View

18.

Tanaka M, Okada H, Hashimoto Y, Kumagai M, Nishimura H, Fukui M . Trunk muscle quality and quantity predict the development of metabolic syndrome and the increase in the number of its components in individuals without metabolic syndrome. Nutr Metab Cardiovasc Dis. 2020; 30(7):1161-1168. DOI: 10.1016/j.numecd.2020.02.021. View

19.

Kim H, Choe J, Kim H, Bae S, Kim B, Lee S . Negative association between metabolic syndrome and bone mineral density in Koreans, especially in men. Calcif Tissue Int. 2010; 86(5):350-8. DOI: 10.1007/s00223-010-9347-2. View

20.

Popa F, Stanciu M, Banciu A, Berteanu M . ASSOCIATION BETWEEN LOW BONE MINERAL DENSITY, METABOLIC SYNDROME AND SEX STEROIDS DEFICIENCY IN MEN. Acta Endocrinol (Buchar). 2019; 12(4):418-422. PMC: 6535234. DOI: 10.4183/aeb.2016.418. View