Microevolution of Driven by Geographic and Host Factors
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Importance: has been reported worldwide and shown to infect humans. Up to now, an effective transmission route of to humans has not been confirmed. The genetic evolution of and the relationship between and its host need to be further studied. The factors driving the genetic diversity of are still controversial. The results showed that the European isolates shared a common ancestor with the Chinese isolates. Host factors were shown to play an important role in driving the genetic diversity of . When host factors were fixed, geographic barriers drove microevolution. Our study emphasizes the importance of characterizing isolate genomes derived from hosts and geographical locations and provides a new reference for the origin of .