Prospective Comparison of FOCUS MUSE and Single-Shot Echo-Planar Imaging for Diffusion-Weighted Imaging in Evaluating Thyroid-Associated Ophthalmopathy

Overview

Journal Korean J Radiol

Specialty Radiology

Date 2024 Sep 30

PMID 39344548

Authors

Yunmeng Wang

Yuanyuan Cui

Jiankun Dai

Shuangshuang Ni

Tianran Zhang

Xin Chen

Qinling Jiang

Yuxin Cheng

Yichuan Ma

Tuo Li

Yi Xiao

Affiliations

Soon will be listed here.

Abstract

Objective: To prospectively compare single-shot (SS) echo-planar imaging (EPI) and field-of-view optimized and constrained undistorted single-shot multiplexed sensitivity-encoding (FOCUS MUSE) for diffusion-weighted imaging (DWI) in evaluating thyroid-associated ophthalmopathy (TAO).

Materials And Methods: SS EPI and FOCUS MUSE DWIs were obtained from 39 patients with TAO (18 male; mean ± standard deviation: 48.3 ± 13.3 years) and 26 healthy controls (9 male; mean ± standard deviation: 43.0 ± 18.5 years). Two radiologists scored the visual image quality using a 4-point Likert scale. The image quality score, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and apparent diffusion coefficient (ADC) of extraocular muscles (EOMs) were compared between the two DWIs. Differences in the ADC of EOMs were also evaluated. The performance of discriminating active from inactive TAO was assessed using receiver operating characteristic curves. The correlation between ADC and clinical activity score (CAS) was analyzed using Spearman correlation.

Results: Compared with SS EPI DWI, FOCUS MUSE DWI demonstrated significantly higher image quality scores ( < 0.001), a higher SNR and CNR on the lateral rectus muscle (LRM) and medial rectus muscle (MRM) ( < 0.05), and a non-significant difference in the ADC of the LRM and MRM. Active TAO showed higher ADC than inactive TAO and healthy controls with both SS EPI and FOCUS MUSE DWIs ( < 0.001). Inactive TAO and healthy controls did not show a significant ADC difference with both DWIs. Compared with SS EPI DWI, FOCUS MUSE DWI demonstrated better discrimination of active from inactive TAO (AUC: 0.925 vs. 0.779; = 0.007). The ADC was significantly correlated with CAS in SS EPI DWI ( = 0.391, < 0.001) and FOCUS MUSE DWI ( = 0.645, < 0.001).

Conclusion: FOCUS MUSE DWI provides better images for evaluating EOMs and better performance in diagnosing active TAO than SS EPI DWI. The application of FOCUS MUSE will facilitate the DWI evaluation of TAO.

Citing Articles

The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy.

Zhou W, Song Y, Shi J, Li T Diagnostics (Basel). 2025; 15(3).

PMID: 39941318 PMC: 11817439. DOI: 10.3390/diagnostics15030388.

References

Higashiyama T, Nishida Y, Morino K, Ugi S, Nishio Y, Maegawa H . Use of MRI signal intensity of extraocular muscles to evaluate methylprednisolone pulse therapy in thyroid-associated ophthalmopathy. Jpn J Ophthalmol. 2014; 59(2):124-30. DOI: 10.1007/s10384-014-0365-x. View

Peng Y, Tang H, Hu X, Shen Y, Kamel I, Li Z . Rectal Cancer Invasiveness: Whole-Lesion Diffusion-Weighted Imaging (DWI) Histogram Analysis by Comparison of Reduced Field-of-View and Conventional DWI Techniques. Sci Rep. 2019; 9(1):18760. PMC: 6904447. DOI: 10.1038/s41598-019-55059-0. View

Saritas E, Cunningham C, Lee J, Han E, Nishimura D . DWI of the spinal cord with reduced FOV single-shot EPI. Magn Reson Med. 2008; 60(2):468-73. DOI: 10.1002/mrm.21640. View

Abdel Razek A, El-Hadidy M, Moawad M, El-Metwaly N, El-Said A . Performance of apparent diffusion coefficient of medial and lateral rectus muscles in Graves' orbitopathy. Neuroradiol J. 2017; 30(3):230-234. PMC: 5480799. DOI: 10.1177/1971400917691993. View

Burch H, Perros P, Bednarczuk T, Cooper D, Dolman P, Leung A . Management of Thyroid Eye Disease: A Consensus Statement by the American Thyroid Association and the European Thyroid Association. Thyroid. 2022; 32(12):1439-1470. PMC: 9807259. DOI: 10.1089/thy.2022.0251. View

Bai Y, Pei Y, Liu W, Liu W, Xie S, Wang X . MRI: Evaluating the Application of FOCUS-MUSE Diffusion-Weighted Imaging in the Pancreas in Comparison With FOCUS, MUSE, and Single-Shot DWIs. J Magn Reson Imaging. 2022; 57(4):1156-1171. DOI: 10.1002/jmri.28382. View

Riffel P, Michaely H, Morelli J, Pfeuffer J, Attenberger U, Schoenberg S . Zoomed EPI-DWI of the pancreas using two-dimensional spatially-selective radiofrequency excitation pulses. PLoS One. 2014; 9(3):e89468. PMC: 3940598. DOI: 10.1371/journal.pone.0089468. View

Dong H, Li Y, Li H, Wang B, Hu B . Study of the reduced field-of-view diffusion-weighted imaging of the breast. Clin Breast Cancer. 2014; 14(4):265-71. DOI: 10.1016/j.clbc.2013.12.001. View

Semelka R, Kelekis N, Thomasson D, Brown M, Laub G . HASTE MR imaging: description of technique and preliminary results in the abdomen. J Magn Reson Imaging. 1996; 6(4):698-9. DOI: 10.1002/jmri.1880060420. View

10.

Lee K, Kessler D, Dezonie S, Chishaya W, Shepherd C, Carmo B . Assessment of deep learning-based reconstruction on T2-weighted and diffusion-weighted prostate MRI image quality. Eur J Radiol. 2023; 166:111017. DOI: 10.1016/j.ejrad.2023.111017. View

11.

Mourits M, Koornneef L, Wiersinga W, Prummel M, Berghout A, van der Gaag R . Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach. Br J Ophthalmol. 1989; 73(8):639-44. PMC: 1041835. DOI: 10.1136/bjo.73.8.639. View

12.

Chang H, Chen G, Chung H, Wu P, Liang L, Juan C . Multi-shot Diffusion-Weighted MRI With Multiplexed Sensitivity Encoding (MUSE) in the Assessment of Active Inflammation in Crohn's Disease. J Magn Reson Imaging. 2021; 55(1):126-137. DOI: 10.1002/jmri.27801. View

13.

Riffel P, Michaely H, Morelli J, Pfeuffer J, Attenberger U, Schoenberg S . Zoomed EPI-DWI of the head and neck with two-dimensional, spatially-selective radiofrequency excitation pulses. Eur Radiol. 2014; 24(10):2507-12. DOI: 10.1007/s00330-014-3287-6. View

14.

Kim Y, Kim M, Gho S, Seo N . Comparison of multiplexed sensitivity encoding and single-shot echo-planar imaging for diffusion-weighted imaging of the liver. Eur J Radiol. 2020; 132:109292. DOI: 10.1016/j.ejrad.2020.109292. View

15.

Iima M, Partridge S, Le Bihan D . Six DWI questions you always wanted to know but were afraid to ask: clinical relevance for breast diffusion MRI. Eur Radiol. 2020; 30(5):2561-2570. DOI: 10.1007/s00330-019-06648-0. View

16.

Tortora F, Prudente M, Cirillo M, Elefante A, Belfiore M, Romano F . Diagnostic accuracy of short-time inversion recovery sequence in Graves' Ophthalmopathy before and after prednisone treatment. Neuroradiology. 2014; 56(5):353-61. DOI: 10.1007/s00234-014-1332-4. View

17.

Li Z, Pipe J, Lee C, Debbins J, Karis J, Huo D . X-PROP: a fast and robust diffusion-weighted propeller technique. Magn Reson Med. 2011; 66(2):341-7. DOI: 10.1002/mrm.23033. View

18.

Fu Q, Kong X, Liu D, Zhou K, Guo Y, Lei Z . Turbo Gradient and Spin Echo PROPELLER-Diffusion Weighted Imaging for Orbital Tumors: A Comparative Study With Readout-Segmented Echo-Planar Imaging. Front Neurosci. 2021; 15:755327. PMC: 8670178. DOI: 10.3389/fnins.2021.755327. View

19.

Chen N, Guidon A, Chang H, Song A . A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE). Neuroimage. 2013; 72:41-7. PMC: 3602151. DOI: 10.1016/j.neuroimage.2013.01.038. View

20.

Fu Q, Liu D, Ma H, Zhou K, Yin T, Zheng C . Turbo Gradient and Spin-Echo BLADE-DWI for Extraocular Muscles in Thyroid-Associated Ophthalmopathy. J Clin Med. 2023; 12(1). PMC: 9821770. DOI: 10.3390/jcm12010344. View