The Evolution of Vaccines Development Across Serovars Among Animal Hosts: A Systematic Review

Overview

Journal Vaccines (Basel)

Date 2024 Sep 28

PMID 39340097

Authors

Abubakar Siddique

Zining Wang

Haiyang Zhou

Linlin Huang

Chenghao Jia

Baikui Wang

Abdelaziz Ed-Dra

Lin Teng

Yan Li

Min Yue

Affiliations

Soon will be listed here.

Abstract

is a significant zoonotic foodborne pathogen, and the global spread of multidrug-resistant (MDR) strains poses substantial challenges, necessitating alternatives to antibiotics. Among these alternatives, vaccines protect the community against infectious diseases effectively. This review aims to summarize the efficacy of developed vaccines evaluated in various animal hosts and highlight key transitions for future vaccine studies. A total of 3221 studies retrieved from Web of Science, Google Scholar, and PubMed/Medline databases between 1970 and 2023 were evaluated. One hundred twenty-seven qualified studies discussed the vaccine efficacy against typhoidal and nontyphoidal serovars, including live-attenuated vaccines, killed inactivated vaccines, outer membrane vesicles, outer membrane complexes, conjugate vaccines, subunit vaccines, and the reverse vaccinology approach in different animal hosts. The most efficacious vaccine antigen candidate found was recombinant heat shock protein (rHsp60) with an incomplete Freund's adjuvant evaluated in a murine model. Overall, bacterial ghost vaccine candidates demonstrated the highest efficacy at 91.25% (95% CI = 83.69-96.67), followed by the reverse vaccinology approach at 83.46% (95% CI = 68.21-94.1) across animal hosts. More than 70% of vaccine studies showed significant production of immune responses, including humoral and cellular, against infection. Collectively, the use of innovative methods rather than traditional approaches for the development of new effective vaccines is crucial and warrants in-depth studies.

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References

Hu M, Zhao W, Li H, Gu J, Yan Q, Zhou X . Immunization with recombinant Salmonella expressing SspH2-EscI protects mice against wild type Salmonella infection. BMC Vet Res. 2018; 14(1):79. PMC: 5845362. DOI: 10.1186/s12917-018-1404-5. View

de la Cruz M, Conrado I, Nault A, Perez A, Dominguez L, Alvarez J . Vaccination as a control strategy against Salmonella infection in pigs: A systematic review and meta-analysis of the literature. Res Vet Sci. 2017; 114:86-94. DOI: 10.1016/j.rvsc.2017.03.005. View

Honda-Okubo Y, Cartee R, Thanawastien A, Yang J, Killeen K, Petrovsky N . A typhoid fever protein capsular matrix vaccine candidate formulated with Advax-CpG adjuvant induces a robust and durable anti-typhoid Vi polysaccharide antibody response in mice, rabbits and nonhuman primates. Vaccine. 2022; 40(32):4625-4634. DOI: 10.1016/j.vaccine.2022.06.043. View

Hsu S, Chen T, Wang C . Efficacy of avian influenza vaccine in poultry: a meta-analysis. Avian Dis. 2011; 54(4):1197-209. DOI: 10.1637/9305-031710-Reg.1. View

Li J, Qiu J, Huang Z, Liu T, Pan J, Zhang Q . Reverse vaccinology approach for the identifications of potential vaccine candidates against Salmonella. Int J Med Microbiol. 2021; 311(5):151508. DOI: 10.1016/j.ijmm.2021.151508. View

De Ridder L, Maes D, Dewulf J, Pasmans F, Boyen F, Haesebrouck F . Effect of a DIVA vaccine with and without in-feed use of coated calcium-butyrate on transmission of Salmonella Typhimurium in pigs. BMC Vet Res. 2013; 9:243. PMC: 4235050. DOI: 10.1186/1746-6148-9-243. View

Wisner A, Desin T, Lam P, Berberov E, Mickael C, Townsend H . Immunization of chickens with Salmonella enterica subspecies enterica serovar Enteritidis pathogenicity island-2 proteins. Vet Microbiol. 2011; 153(3-4):274-84. DOI: 10.1016/j.vetmic.2011.05.041. View

Ferrari R, Rosario D, Cunha-Neto A, Mano S, Figueiredo E, Conte-Junior C . Worldwide Epidemiology of Serovars in Animal-Based Foods: a Meta-analysis. Appl Environ Microbiol. 2019; 85(14). PMC: 6606869. DOI: 10.1128/AEM.00591-19. View

Wang Z, Zhou H, Liu Y, Huang C, Chen J, Siddique A . Nationwide trends and features of human salmonellosis outbreaks in China. Emerg Microbes Infect. 2024; 13(1):2372364. PMC: 11259058. DOI: 10.1080/22221751.2024.2372364. View

10.

Graziani C, Busani L, Dionisi A, Lucarelli C, Owczarek S, Ricci A . Antimicrobial resistance in Salmonella enterica serovar Typhimurium from human and animal sources in Italy. Vet Microbiol. 2007; 128(3-4):414-8. DOI: 10.1016/j.vetmic.2007.10.017. View

11.

Schuster O, Sears K, Ramachandran G, Fuche F, Curtis B, Tennant S . Immunogenicity and protective efficacy against C-C infection in mice immunized with a glycoconjugate of Newport Core-O polysaccharide linked to the homologous serovar FliC protein. Hum Vaccin Immunother. 2018; 15(6):1436-1444. PMC: 6663135. DOI: 10.1080/21645515.2018.1483808. View

12.

Acevedo-Villanueva K, Akerele G, Al-Hakeem W, Adams D, Gourapura R, Selvaraj R . Immunization of Broiler Chickens With a Killed Chitosan Nanoparticle Vaccine Decreases Enterica Serovar Enteritidis Load. Front Physiol. 2022; 13:920777. PMC: 9340066. DOI: 10.3389/fphys.2022.920777. View

13.

Cooper G, Venables L, Nicholas R, Cullen G, Hormaeche C . Vaccination of chickens with chicken-derived Salmonella enteritidis phage type 4 aroA live oral Salmonella vaccines. Vaccine. 1992; 10(4):247-54. DOI: 10.1016/0264-410x(92)90160-l. View

14.

Fuche F, Jones J, Ramachandran G, Higginson E, Simon R, Tennant S . Deletions in and but not or constitute a live-attenuated vaccine strain of Newport to protect against serogroup CC in mice. Hum Vaccin Immunother. 2018; 15(6):1427-1435. PMC: 6663134. DOI: 10.1080/21645515.2018.1491499. View

15.

Wang X, Kang X, Pan M, Wang M, Zhang J, Song H . Evaluation of the Protective Immune Response Induced by an Deficient Salmonella enterica Serovar Enteritidis Strain as a Live Attenuated DIVA (Differentiation of Infected and Vaccinated Animals) Vaccine in Chickens. Microbiol Spectr. 2022; 10(6):e0157422. PMC: 9769753. DOI: 10.1128/spectrum.01574-22. View

16.

Garcia-Seco T, Montbrau C, Fontseca M, March R, Sitja M, Dominguez L . Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes. Res Vet Sci. 2020; 135:486-494. DOI: 10.1016/j.rvsc.2020.11.017. View

17.

Vij S, Thakur R, Rishi P . Reverse engineering approach: a step towards a new era of vaccinology with special reference to . Expert Rev Vaccines. 2022; 21(12):1763-1785. DOI: 10.1080/14760584.2022.2148661. View

18.

Sharma S, Solanki V, Tiwari V . Reverse vaccinology approach to design a vaccine targeting membrane lipoproteins of . J Biomol Struct Dyn. 2021; 41(3):954-969. DOI: 10.1080/07391102.2021.2015443. View

19.

Dodd C, Renter D, Thomson D, Nagaraja T . Evaluation of the effects of a commercially available Salmonella Newport siderophore receptor and porin protein vaccine on fecal shedding of Salmonella bacteria and health and performance of feedlot cattle. Am J Vet Res. 2011; 72(2):239-47. DOI: 10.2460/ajvr.72.2.239. View

20.

Li Y, Ed-Dra A, Tang B, Kang X, Muller A, Kehrenberg C . Higher tolerance of predominant Salmonella serovars circulating in the antibiotic-free feed farms to environmental stresses. J Hazard Mater. 2022; 438:129476. DOI: 10.1016/j.jhazmat.2022.129476. View