Combined Aerobic Exercise Training and Intake Reduces Arterial Stiffness Through Enhanced Arterial Nitric Oxide Production in Obese Rats

Overview

Journal Nutrients

Date 2024 Sep 28

PMID 39339680

Authors

Henry Yamazaki

Shumpei Fujie

Kenichiro Inoue

Masataka Uchida

Motoyuki Iemitsu

Affiliations

Soon will be listed here.

Abstract

This study aimed to assess the effect of a combination of aerobic exercise training (ET) and (CH) intake on arterial nitric oxide (NO) production and arterial stiffness in obese rats. Twenty-week-old obese male rats were randomly grouped into four ( = 6): OBESE-SED (sedentary control), OBESE-ET (treadmill 25 m/min, 1 h, 5 d/week), OBESE-CH (0.5% powder in normal diet), and OBESE-ET+CH (combination of ET and CH intake) groups. The carotid-femoral pulse wave velocity (cfPWV), an index of arterial stiffness, was significantly lesser in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and in the OBESE-ET+CH group significantly further enhanced these effects compared with the OBESE-ET and OBESE-CH groups. Additionally, arterial nitrate/nitrite (NOx) levels were significantly greater in the OBESE-ET, OBESE-CH, and OBESE-ET+CH groups than in the OBESE-SED group, and the OBESE-ET+CH group compared with the OBESE-ET and OBESE-CH groups. Furthermore, arterial NOx levels were positively correlated with arterial endothelial NO synthase phosphorylation levels (r = 0.489, 0.05) and negatively correlated with cfPWV (r = -0.568, 0.05). In conclusion, a combination of ET and CH intake may reduce arterial stiffness via an enhancement of the arterial NO signaling pathway in obese rats.

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