Novel Iridoid Derivatives Isolated from the Roots of with Potential Anti-Renal Fibrosis Activity In Vitro

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Sep 28

PMID 39339414

Authors

Ziran Li

Yang Xu

Xu Sun

Zhangrui Fan

Ziling Zhou

Fucai Ren

Ning Li

Lei Di

Affiliations

Soon will be listed here.

Abstract

Scabrol B and Scabrol C, two newly identified iridoid derivatives ( and ) and six known compounds (-), were extracted from the roots of . The structures of these derivatives, including their absolute configurations, were elucidated via comprehensive NMR analysis, chemical derivatization, and quantum chemical ECD calculations. All isolated compounds were evaluated for their anti-renal fibrosis activity. The results demonstrate that compounds and showed dose-dependent protective effects against renal fibrosis in vitro by reducing the expression of fibronectin, collagen I, and alpha-smooth muscle actin (-SMA) in NRK-49f cells mediated by TGF-1.

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