2-Bromopyridines As Versatile Synthons for Heteroarylated 2-Pyridones Via Ru(II)-Mediated Domino C-O/C-N/C-C Bond Formation Reactions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Sep 28

PMID 39339413

Authors

Miha Drev

Helena Brodnik

Uros Groselj

Franc Perdih

Jurij Svete

Bogdan Stefane

Franc Pozgan

Affiliations

Soon will be listed here.

Abstract

A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)-KOPiv-NaCO catalytic system. Unsubstituted 2-bromopyridine was successfully converted to the penta-heteroarylated 2-pyridone product using this method. Preliminary mechanistic studies revealed a possible synthetic pathway leading to the multi-heteroarylated 2-pyridone products, involving consecutive oxygen incorporation, a Buchwald-Hartwig-type reaction, and C-H bond activation.

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