Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Sep 28

PMID 39339303

Authors

Jelena Dinic

Ana Podolski-Renic

Miroslav Novakovic

Liang Li

Igor Opsenica

Milica Pesic

Affiliations

Soon will be listed here.

Abstract

Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in addressing multidrug resistance in cancer therapy. Additionally, we discuss the modulation of P-gp activity by 55 natural product drugs, including derivatives for some of them, based on our team's research findings since 2011. Specifically, we prospect into sesquiterpenoids from the genera , , , , , and ; diterpenoids from the genera and ; chalcones from the genera , , , , and ; riccardins from the genera , , , , and ; and diarylheptanoids from the genera and . Through comprehensive analysis, we aim to highlight the potential of natural products mainly identified in plants from Serbia in influencing P-gp activity and overcoming drug resistance in cancer therapy, while also providing insights into future perspectives in this field.

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