Nutritional Epigenomics: Bioactive Dietary Compounds in the Epigenetic Regulation of Osteoarthritis

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2024 Sep 28

PMID 39338311

Authors

Karla Mariuxi Villagran-Andrade

Carmen Nunez-Carro

Francisco J Blanco

Maria C de Andres

Affiliations

Soon will be listed here.

Abstract

Nutritional epigenomics is exceptionally important because it describes the complex interactions among food compounds and epigenome modifications. Phytonutrients or bioactive compounds, which are secondary metabolites of plants, can protect against osteoarthritis by suppressing the expression of inflammatory and catabolic mediators, modulating epigenetic changes in DNA methylation, and the histone or chromatin remodelling of key inflammatory genes and noncoding RNAs. The combination of natural epigenetic modulators is crucial because of their additive and synergistic effects, safety and therapeutic efficacy, and lower adverse effects than conventional pharmacology in the treatment of osteoarthritis. In this review, we have summarized the chondroprotective properties of bioactive compounds used for the management, treatment, or prevention of osteoarthritis in both human and animal studies. However, further research is needed into bioactive compounds used as epigenetic modulators in osteoarthritis, in order to determine their potential value for future clinical applications in osteoarthritic patients as well as their relation with the genomic and nutritional environment, in order to personalize food and nutrition together with disease prevention.

Citing Articles

The Impact of Gestational Diabetes on Kidney Development: is There an Epigenetic Link?.

Tortelote G Curr Diab Rep. 2024; 25(1):13.

PMID: 39690358 PMC: 11652566. DOI: 10.1007/s11892-024-01569-9.

References

Ye H, Long Y, Yang J, Wu Y, Dong L, Zhong Y . Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model. Sci Rep. 2024; 14(1):8176. PMC: 11001965. DOI: 10.1038/s41598-024-58375-2. View

Pan L, Zhang Y, Chen N, Yang L . Icariin Regulates Cellular Functions and Gene Expression of Osteoarthritis Patient-Derived Human Fibroblast-Like Synoviocytes. Int J Mol Sci. 2018; 18(12). PMC: 5751258. DOI: 10.3390/ijms18122656. View

Khan N, Haqqi T . Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics. Pharmacol Res. 2017; 128:73-79. PMC: 5803377. DOI: 10.1016/j.phrs.2017.08.007. View

Liang C, Xing H, Wang C, Xu X, Hao Y, Qiu B . Resveratrol protection against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signaling pathway. J Orthop Surg Res. 2022; 17(1):406. PMC: 9446849. DOI: 10.1186/s13018-022-03306-y. View

Liu Y, Mi B, Lv H, Liu J, Xiong Y, Hu L . Shared KEGG pathways of icariin-targeted genes and osteoarthritis. J Cell Biochem. 2018; 120(5):7741-7750. DOI: 10.1002/jcb.28048. View

Montgomery M, Srinivasan A . Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention. Adv Nutr. 2019; 10(6):1012-1028. PMC: 6855955. DOI: 10.1093/advances/nmz046. View

Hu S, Wang S, He J, Bian Y . Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes. Mol Med Rep. 2021; 25(1). PMC: 8600404. DOI: 10.3892/mmr.2021.12528. View

Chin K, Pang K . Therapeutic Effects of Olive and Its Derivatives on Osteoarthritis: From Bench to Bedside. Nutrients. 2017; 9(10). PMC: 5691677. DOI: 10.3390/nu9101060. View

Kouzarides T . Chromatin modifications and their function. Cell. 2007; 128(4):693-705. DOI: 10.1016/j.cell.2007.02.005. View

10.

Jia T, Qiao J, Guan D, Chen T . Anti-Inflammatory Effects of Licochalcone A on IL-1β-Stimulated Human Osteoarthritis Chondrocytes. Inflammation. 2017; 40(6):1894-1902. DOI: 10.1007/s10753-017-0630-5. View

11.

Rufino A, Ribeiro M, Sousa C, Judas F, Salgueiro L, Cavaleiro C . Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis. Eur J Pharmacol. 2015; 750:141-50. DOI: 10.1016/j.ejphar.2015.01.018. View

12.

Rasheed Z, Rasheed N, Al-Shobaili H . Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes. J Cell Mol Med. 2016; 20(12):2241-2248. PMC: 5134388. DOI: 10.1111/jcmm.12897. View

13.

Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T . The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study. Clin Med Insights Arthritis Musculoskelet Disord. 2020; 13:1179544120948471. PMC: 7425263. DOI: 10.1177/1179544120948471. View

14.

Chen W, Bao T, Chen K, Zhu C, Wan F, Tan Y . [Effects of geniposide on SNP-induced apoptosis of chondrocyte and cell cycle]. Zhongguo Gu Shang. 2013; 26(3):232-5. View

15.

Al-Afify A, El-Akabawy G, El-Sherif N, El-Safty F, El-Habiby M . Avocado soybean unsaponifiables ameliorates cartilage and subchondral bone degeneration in mono-iodoacetate-induced knee osteoarthritis in rats. Tissue Cell. 2018; 52:108-115. DOI: 10.1016/j.tice.2018.05.001. View

16.

Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg V, Haqqi T . Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med. 2002; 33(8):1097-105. DOI: 10.1016/s0891-5849(02)01004-3. View

17.

Tuddenham L, Wheeler G, Ntounia-Fousara S, Waters J, Hajihosseini M, Clark I . The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett. 2006; 580(17):4214-7. DOI: 10.1016/j.febslet.2006.06.080. View

18.

McKay J, Mathers J . Diet induced epigenetic changes and their implications for health. Acta Physiol (Oxf). 2011; 202(2):103-18. DOI: 10.1111/j.1748-1716.2011.02278.x. View

19.

Heinecke L, Grzanna M, Au A, Mochal C, Rashmir-Raven A, Frondoza C . Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate. Osteoarthritis Cartilage. 2009; 18(2):220-7. DOI: 10.1016/j.joca.2009.08.015. View

20.

Zhong Y, Huang Y, Santoso M, Wu L . Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int J Clin Exp Pathol. 2015; 8(3):2365-74. PMC: 4440052. View