A-Allele As a Biomarker for Periodontitis Severity in Bulgarian Patients

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Sep 28

PMID 39336814

Authors

Zdravka Pashova-Tasseva

Velitchka Dosseva-Panova

Antoaneta Mlachkova

Alexey Savov

Ekaterina Tosheva

Affiliations

Soon will be listed here.

Abstract

Background: Periodontitis is a complex disease, and bacterial factors play a crucial role in its initiation. The contributions of genetic and epigenetic factors to the pathogenesis of periodontal disease are increasingly recognized. Single-nucleotide polymorphisms (SNPs) in various molecules, including cytokines, are of particular interest due to their established involvement in numerous diseases. This study investigates the influence of SNPs in the gene at positions and (also referred to as ) on the severity of periodontitis in a cohort of Bulgarian patients.

Methods: In the recent study, both clinical and paraclinical methodologies were employed to comprehensively assess the periodontal status of the participants. The genotypic characterization of polymorphisms was performed by PCR RFLP analysis. Statistical analyses, including principal component analysis (PCA), were executed utilizing IBM SPSS Statistics Version 21.

Results: We have established a statistically significant association between the presence of at least one A-allele in the patients' genotype and the incidence of severe periodontitis ( = 0.047).

Conclusions: single-nucleotide polymorphisms (SNPs) could be effectively considered as biomarkers for the severity of periodontitis.

References

Ji S, Choi Y, Choi Y . Bacterial invasion and persistence: critical events in the pathogenesis of periodontitis?. J Periodontal Res. 2014; 50(5):570-85. DOI: 10.1111/jre.12248. View

Khdair S, Al-Naimat O, Jarrar W, Al-Qerem W, Khudeir F . The Influence of TNF-α, IL-6, TGF-β1, IFN-γ, IL-10 Polymorphisms on Predisposition to Diabetes Mellitus among Jordanian Patients. Endocr Metab Immune Disord Drug Targets. 2022; 23(5):681-691. DOI: 10.2174/1871530322666220827143530. View

Ebersole J, Dawson 3rd D, Emecen-Huja P, Nagarajan R, Howard K, Grady M . The periodontal war: microbes and immunity. Periodontol 2000. 2017; 75(1):52-115. DOI: 10.1111/prd.12222. View

Thomas S, Muruganantham J, Veerabathiran R . Meta-analysis of interleukin-10 gene polymorphisms and tuberculosis susceptibility: Insights from recent studies. Hum Antibodies. 2024; 32(4):169-179. DOI: 10.3233/HAB-240024. View

Toker H, Gorgun E, Korkmaz E, Balci Yuce H, Poyraz O . The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis. J Appl Oral Sci. 2018; 26:e20170232. PMC: 5829549. DOI: 10.1590/1678-7757-2017-0232. View

Mitani A, Niedbala W, Fujimura T, Mogi M, Miyamae S, Higuchi N . Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis. J Periodontol. 2014; 86(2):301-9. DOI: 10.1902/jop.2014.140293. View

Heitz-Mayfield L . Conventional diagnostic criteria for periodontal diseases (plaque-induced gingivitis and periodontitis). Periodontol 2000. 2024; 95(1):10-19. DOI: 10.1111/prd.12579. View

Vakili M, Shirinzadeh-Dastgiri A, Ershadi R, Dastgheib S, Shiri A, Aghasipour M . Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk. Asian Pac J Cancer Prev. 2024; 25(1):287-298. PMC: 10911735. DOI: 10.31557/APJCP.2024.25.1.287. View

Kassebaum N, Bernabe E, Dahiya M, Bhandari B, Murray C, Marcenes W . Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014; 93(11):1045-53. PMC: 4293771. DOI: 10.1177/0022034514552491. View

10.

Silveira V, Pigossi S, Scarel-Caminaga R, Cirelli J, Rego R, Nogueira N . Analysis of polymorphisms in Interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis. Braz Oral Res. 2016; 30(1):e105. DOI: 10.1590/1807-3107BOR-2016.vol30.0105. View

11.

McGuire M, Nunn M . Prognosis versus actual outcome. III. The effectiveness of clinical parameters in accurately predicting tooth survival. J Periodontol. 1996; 67(7):666-74. DOI: 10.1902/jop.1996.67.7.666. View

12.

Di Spirito F, Di Palo M, Rupe A, Piedepalumbo F, Sessa A, De Benedetto G . Periodontitis in Psoriatic Patients: Epidemiological Insights and Putative Etiopathogenic Links. Epidemiologia (Basel). 2024; 5(3):479-498. PMC: 11348036. DOI: 10.3390/epidemiologia5030033. View

13.

Eke P, Dye B, Wei L, Thornton-Evans G, Genco R . Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012; 91(10):914-20. DOI: 10.1177/0022034512457373. View

14.

Suvan J, Leira Y, Moreno Sancho F, Graziani F, Derks J, Tomasi C . Subgingival instrumentation for treatment of periodontitis. A systematic review. J Clin Periodontol. 2020; 47 Suppl 22:155-175. DOI: 10.1111/jcpe.13245. View

15.

Jonsson J, Purdie D, Bansal A, Shorthouse C, Powell E . Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology. 1999; 30(2):526-30. DOI: 10.1002/hep.510300207. View

16.

Heitz-Mayfield L, Lang N . Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013; 62(1):218-31. DOI: 10.1111/prd.12008. View

17.

Gonzales J, Michel J, Diete A, Herrmann J, Bodeker R, Meyle J . Analysis of genetic polymorphisms at the interleukin-10 loci in aggressive and chronic periodontitis. J Clin Periodontol. 2002; 29(9):816-22. DOI: 10.1034/j.1600-051x.2002.290905.x. View

18.

Inchingolo F, Martelli F, Isacco C, Borsani E, Cantore S, Corcioli F . Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients. Biomedicines. 2020; 8(5). PMC: 7277173. DOI: 10.3390/biomedicines8050115. View

19.

Mohammadi S, Jazi M, Zare Ebrahimabad M, Eghbalpour F, Abdolahi N, Tabarraei A . Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population. Int J Immunogenet. 2018; 46(1):20-30. DOI: 10.1111/iji.12407. View

20.

Lopes C, Barroso R, Burbano R, Garcia P, do Carmo Pinto P, Dos Santos N . Effect of ancestry on haplotypes in chronic periodontitis. Front Biosci (Elite Ed). 2017; 9(2):276-285. DOI: 10.2741/e802. View