Genetic Foundations of Nellore Traits: A Gene Prioritization and Functional Analyses of Genome-Wide Association Study Results

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Sep 28

PMID 39336722

Authors

Adebisi R Ogunbawo

Henrique A Mulim

Gabriel S Campos

Hinayah R Oliveira

Affiliations

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Abstract

The main goal of this study was to pinpoint functional candidate genes associated with multiple economically important traits in Nellore cattle. After quality control, 1830 genomic regions sourced from 52 scientific peer-reviewed publications were used in this study. From these, a total of 8569 positional candidate genes were annotated for reproduction, 11,195 for carcass, 5239 for growth, and 3483 for morphological traits, and used in an over-representation analysis. The significant genes (adjusted -values < 0.05) identified in the over-representation analysis underwent prioritization analyses, and enrichment analysis of the prioritized over-represented candidate genes was performed. The prioritized candidate genes were , , , , , and for reproduction; , , , , , , , , , and for the carcass; and for growth traits; and no genes were prioritized for morphological traits. The functional analysis pinpointed the following genes: (plays a crucial role in spindle organization, which is essential in forming a robust mitotic centrosome), (involved in muscle cell differentiation), and (involved in protein deubiquitination, thereby improving growth). The enrichment of the functional candidate genes identified in this study highlights that these genes play an important role in the expression of reproduction, carcass, and growth traits in Nellore cattle.

Citing Articles

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