As a Source of Immunomodulatory Agents: A New Opportunity and Perspective

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2024 Sep 28

PMID 39336171

Authors

Ahmad Hafidul Ahkam

Yasmiwar Susilawati

Sri Adi Sumiwi

Affiliations

Soon will be listed here.

Abstract

Immunomodulators are pivotal in managing various health conditions by regulating the immune response by either enhancing or suppressing it to maintain homeostasis. The growing interest in natural sources of immunomodulatory agents has spurred the investigation of numerous medicinal plants, including , commonly known in Asia as sungkai. Traditionally used for its medicinal properties in Southeast Asia, belongs to the Verbenaceae family and has garnered significant attention. This review discusses the immunomodulatory activity of the active compounds in and explores the potential directions for future research.

References

Strzelec M, Detka J, Mieszczak P, Sobocinska M, Majka M . Immunomodulation-a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system. Front Immunol. 2023; 14:1127704. PMC: 10033545. DOI: 10.3389/fimmu.2023.1127704. View

Rahman T, Das A, Abir M, Nafiz I, Mahmud A, Sarker M . Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts. Cytokine. 2023; 169:156268. DOI: 10.1016/j.cyto.2023.156268. View

Granata S, Dalla Gassa A, Carraro A, Brunelli M, Stallone G, Lupo A . Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects. Int J Mol Sci. 2016; 17(5). PMC: 4881557. DOI: 10.3390/ijms17050735. View

Gudoityte E, Arandarcikaite O, Mazeikiene I, Bendokas V, Liobikas J . Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential. Int J Mol Sci. 2021; 22(9). PMC: 8124962. DOI: 10.3390/ijms22094599. View

Enioutina E, Salis E, Job K, Gubarev M, Krepkova L, Sherwin C . Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. Expert Rev Clin Pharmacol. 2016; 10(3):327-338. DOI: 10.1080/17512433.2017.1268917. View

Schmidt E, Wanner J, Hiiferl M, Jirovetz L, Buchbauer G, Gochev V . Chemical composition, olfactory analysis and antibacterial activity of Thymus vulgaris chemotypes geraniol, 4-thujanol/terpinen-4-ol, thymol and linalool cultivated in southern France. Nat Prod Commun. 2012; 7(8):1095-8. View

Lee L, Gupta M, Sahasranaman S . Immune Checkpoint inhibitors: An introduction to the next-generation cancer immunotherapy. J Clin Pharmacol. 2015; 56(2):157-69. DOI: 10.1002/jcph.591. View

Kim G, Choi J . Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Signaling in T-Cell Biology and Disease Therapy. Mol Cells. 2022; 45(8):513-521. PMC: 9385567. DOI: 10.14348/molcells.2022.2056. View

Fischer I, Milton C, Wallace H . Toxicity testing is evolving!. Toxicol Res (Camb). 2020; 9(2):67-80. PMC: 7233318. DOI: 10.1093/toxres/tfaa011. View

10.

Jantan I, Ahmad W, Bukhari S . Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci. 2015; 6:655. PMC: 4548092. DOI: 10.3389/fpls.2015.00655. View

11.

Rahmatullah M, Jahan R, Azam F, Hossan S, Mollik M, Rahman T . Folk medicinal uses of Verbenaceae family plants in Bangladesh. Afr J Tradit Complement Altern Med. 2012; 8(5 Suppl):53-65. PMC: 3252728. DOI: 10.4314/ajtcam.v8i5S.15. View

12.

Yaron J, Zhang L, Guo Q, Burgin M, Schutz L, Awo E . Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics. J Clin Med. 2020; 9(4). PMC: 7230489. DOI: 10.3390/jcm9040972. View

13.

Akdis M, Aab A, Altunbulakli C, Azkur K, Costa R, Crameri R . Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016; 138(4):984-1010. DOI: 10.1016/j.jaci.2016.06.033. View

14.

Perez Zamora C, Torres C, Nunez M . Antimicrobial Activity and Chemical Composition of Essential Oils from Verbenaceae Species Growing in South America. Molecules. 2018; 23(3). PMC: 6017629. DOI: 10.3390/molecules23030544. View

15.

Vicovan A, Petrescu D, Constantinescu D, Iftimi E, Cernescu I, Ancuta C . Experimental Insights on the Use of Secukinumab and Magnolol in Acute Respiratory Diseases in Mice. Biomedicines. 2024; 12(7). PMC: 11275060. DOI: 10.3390/biomedicines12071538. View

16.

Timmermans S, Souffriau J, Libert C . A General Introduction to Glucocorticoid Biology. Front Immunol. 2019; 10:1545. PMC: 6621919. DOI: 10.3389/fimmu.2019.01545. View

17.

Pferschy-Wenzig E, Bauer R . The relevance of pharmacognosy in pharmacological research on herbal medicinal products. Epilepsy Behav. 2015; 52(Pt B):344-62. DOI: 10.1016/j.yebeh.2015.05.037. View

18.

Lee H, Myoung H, Kim S . Review of two immunosuppressants: tacrolimus and cyclosporine. J Korean Assoc Oral Maxillofac Surg. 2023; 49(6):311-323. PMC: 10761313. DOI: 10.5125/jkaoms.2023.49.6.311. View

19.

Liu Q, Ahadpour M, Rocca M, Huang S . Clinical Pharmacology Regulatory Sciences in Drug Development and Precision Medicine: Current Status and Emerging Trends. AAPS J. 2021; 23(3):54. PMC: 8041391. DOI: 10.1208/s12248-021-00563-3. View

20.

Hardman T, Aitchison R, Scaife R, Edwards J, Slater G . The future of clinical trials and drug development: 2050. Drugs Context. 2023; 12. PMC: 10259497. DOI: 10.7573/dic.2023-2-2. View