Closing the Gap: Proposing a Socio-ecological Framework to Make Cancer Clinical Trials More Accessible, Equitable, and Acceptable to Adolescents and Young Adults

Overview

Journal Oncologist

Publisher Oxford University Press

Specialty Oncology

Date 2024 Sep 27

PMID 39331472

Authors

Zeba Ahmad

Vinayak Venkataraman

Michaela Markwart

Annah N Abrams

Jennifer S Temel

Giselle K Perez

Affiliations

Soon will be listed here.

References

Roth M, Unger J, OMara A, Lewis M, Budd T, Johnson R . Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era. Cancer Med. 2020; 9(6):2146-2152. PMC: 7064039. DOI: 10.1002/cam4.2891. View

Shaw P, Boyiadzis M, Tawbi H, Welsh A, Kemerer A, Davidson N . Improved clinical trial enrollment in adolescent and young adult (AYA) oncology patients after the establishment of an AYA oncology program uniting pediatric and medical oncology divisions. Cancer. 2012; 118(14):3614-7. DOI: 10.1002/cncr.26634. View

Hesko C, Mittal N, Avutu V, Thomas S, Heath J, Roth M . Creation of a quality improvement collaborative to address adolescent and young adult cancer clinical trial enrollment: ATAQI (AYA trial access quality initiative). Curr Probl Cancer. 2022; 47(6):100898. PMC: 11077416. DOI: 10.1016/j.currproblcancer.2022.100898. View

Keegan T, Abrahao R, Alvarez E . Survival Trends Among Adolescents and Young Adults Diagnosed With Cancer in the United States: Comparisons With Children and Older Adults. J Clin Oncol. 2023; 42(6):630-641. DOI: 10.1200/JCO.23.01367. View

Gabram S, Lund M, Gardner J, Hatchett N, Bumpers H, Okoli J . Effects of an outreach and internal navigation program on breast cancer diagnosis in an urban cancer center with a large African-American population. Cancer. 2008; 113(3):602-7. DOI: 10.1002/cncr.23568. View

Forcina V, Vakeesan B, Paulo C, Mitchell L, Bell J, Tam S . Perceptions and attitudes toward clinical trials in adolescent and young adults with cancer: a systematic review. Adolesc Health Med Ther. 2018; 9:87-94. PMC: 6005317. DOI: 10.2147/AHMT.S163121. View

Siembida E, Loomans-Kropp H, Trivedi N, OMara A, Sung L, Tami-Maury I . Systematic review of barriers and facilitators to clinical trial enrollment among adolescents and young adults with cancer: Identifying opportunities for intervention. Cancer. 2019; 126(5):949-957. PMC: 7029803. DOI: 10.1002/cncr.32675. View

Holmes D, Major J, Lyonga D, Alleyne R, Clayton S . Increasing minority patient participation in cancer clinical trials using oncology nurse navigation. Am J Surg. 2011; 203(4):415-22. DOI: 10.1016/j.amjsurg.2011.02.005. View

Roth M, Mittal N, Saha A, Freyer D . The Children's Oncology Group Adolescent and Young Adult Responsible Investigator Network: A New Model for Addressing Site-Level Factors Impacting Clinical Trial Enrollment. J Adolesc Young Adult Oncol. 2020; 9(4):522-527. PMC: 7415882. DOI: 10.1089/jayao.2019.0139. View

10.

Siembida E, Loomans-Kropp H, Tami-Maury I, Freyer D, Sung L, Crosswell H . Comparing Barriers and Facilitators to Adolescent and Young Adult Clinical Trial Enrollment Across High- and Low-Enrolling Community-Based Clinics. Oncologist. 2022; 27(5):363-370. PMC: 9074986. DOI: 10.1093/oncolo/oyac030. View

11.

Ell K, Vourlekis B, Xie B, Nedjat-Haiem F, Lee P, Muderspach L . Cancer treatment adherence among low-income women with breast or gynecologic cancer: a randomized controlled trial of patient navigation. Cancer. 2009; 115(19):4606-15. PMC: 2749894. DOI: 10.1002/cncr.24500. View

12.

Miller K, Fidler-Benaoudia M, Keegan T, Hipp H, Jemal A, Siegel R . Cancer statistics for adolescents and young adults, 2020. CA Cancer J Clin. 2020; 70(6):443-459. DOI: 10.3322/caac.21637. View

13.

Parsons H, Penn D, Li Q, Cress R, Pollock B, Malogolowkin M . Increased clinical trial enrollment among adolescent and young adult cancer patients between 2006 and 2012-2013 in the United States. Pediatr Blood Cancer. 2018; 66(1):e27426. PMC: 6249090. DOI: 10.1002/pbc.27426. View

14.

Roth M, Beauchemin M, Kahn J, Bleyer A . Patterns of National Cancer Institute-Sponsored Clinical Trial Enrollment in Black Adolescents and Young Adults. Cancer Med. 2021; 10(21):7620-7628. PMC: 8559464. DOI: 10.1002/cam4.4292. View

15.

Tai E, Buchanan N, Westervelt L, Elimam D, Lawvere S . Treatment setting, clinical trial enrollment, and subsequent outcomes among adolescents with cancer: a literature review. Pediatrics. 2014; 133 Suppl 3:S91-7. PMC: 6075704. DOI: 10.1542/peds.2014-0122C. View

16.

Ellis J, Malalasekera V, Allan C, Choong P, Hansford J, Hehir R . Systems-Level Change to Alleviate Barriers to Cancer Clinical Trial Access for Adolescents and Young Adults in Australia. J Adolesc Young Adult Oncol. 2021; 11(2):173-180. PMC: 9057899. DOI: 10.1089/jayao.2021.0026. View

17.

Salihu H, Wilson R, King L, Marty P, Whiteman V . Socio-ecological Model as a Framework for Overcoming Barriers and Challenges in Randomized Control Trials in Minority and Underserved Communities. Int J MCH AIDS. 2016; 3(1):85-95. PMC: 4948176. View

18.

Wayant C, Fitzgerald K, Hemmerich C, Geng Y, Freyer D, Roth M . Prevalence of Adverse Event Reporting in Adolescents and Young Adults Enrolled in Cancer Clinical Trials. JCO Oncol Pract. 2023; 19(11):1048-1052. PMC: 10667017. DOI: 10.1200/OP.23.00201. View

19.

Keim-Malpass J, Callahan L, Lindley L, Templeman C, Mooney-Doyle K . Perspectives on Access to Novel Therapeutics Through Clinical Trials Among Adolescents and Young Adults with Advanced Cancer: Implications for Patient-Centered Clinical Trials. J Adolesc Young Adult Oncol. 2022; 12(1):53-58. DOI: 10.1089/jayao.2021.0152. View

20.

Lewin J, Bell J, Wang K, Forcina V, Tam S, Srikanthan A . Evaluation of Adolescents' and Young Adults' Attitudes Toward Participation in Cancer Clinical Trials. JCO Oncol Pract. 2020; 16(3):e280-e289. DOI: 10.1200/JOP.19.00450. View