Damage-Associated Molecular Patterns and Pattern Recognition Receptors in the Podocyte

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2024 Sep 27

PMID 39331471

Authors

Robert L Myette

Mayra Trentin-Sonoda

Chloe Landry

Chet E Holterman

Tony Lin

Dylan Burger

Christopher R J Kennedy

Affiliations

Soon will be listed here.

Abstract

Podocytes possess immune system components allowing for a variety of innate responses to endogenous and exogenous stimuli. Recently, several groups have linked inappropriate innate immune signaling to podocyte injury, particularly chronic, sustained injury; however, the immune capabilities of podocytes have not been fully elucidated. Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from damaged cells, including podocytes, and can elicit an inflammatory response and recruit immune cells to areas of injury. This is performed through binding to pattern recognition receptors. Believed largely to be protective and responsive to injury or infection, recent evidence suggests signaling through DAMP pathways can aggravate and promote chronic diseases already associated with inflammation. The purpose of this narrative review was to highlight current knowledge with respect to specific podocyte DAMPs and pattern recognition receptors and to provide insight into ongoing work and possible future research avenues to advance our understanding of podocyte immune mechanisms.

References

Donato R, Cannon B, Sorci G, Riuzzi F, Hsu K, Weber D . Functions of S100 proteins. Curr Mol Med. 2012; 13(1):24-57. PMC: 3707951. View

Wang Y, Liu J, Zhang Q, Wang W, Liu Q, Liu S . Human umbilical cord mesenchymal stem cells attenuate podocyte injury under high glucose via TLR2 and TLR4 signaling. Diabetes Res Clin Pract. 2021; 173:108702. DOI: 10.1016/j.diabres.2021.108702. View

Hou W, Zhang Q, Yan Z, Chen R, Zeh Iii H, Kang R . Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death Dis. 2013; 4:e966. PMC: 3877563. DOI: 10.1038/cddis.2013.493. View

Rong G, Tang X, Guo T, Duan N, Wang Y, Yang L . Advanced oxidation protein products induce apoptosis in podocytes through induction of endoplasmic reticulum stress. J Physiol Biochem. 2015; 71(3):455-70. DOI: 10.1007/s13105-015-0424-x. View

Ma M, Jiang W, Zhou R . DAMPs and DAMP-sensing receptors in inflammation and diseases. Immunity. 2024; 57(4):752-771. DOI: 10.1016/j.immuni.2024.03.002. View

Burke 3rd G, Mitrofanova A, Fontanella A, Ciancio G, Roth D, Ruiz P . The podocyte: glomerular sentinel at the crossroads of innate and adaptive immunity. Front Immunol. 2023; 14:1201619. PMC: 10410139. DOI: 10.3389/fimmu.2023.1201619. View

Zang N, Cui C, Guo X, Song J, Hu H, Yang M . cGAS-STING activation contributes to podocyte injury in diabetic kidney disease. iScience. 2022; 25(10):105145. PMC: 9513272. DOI: 10.1016/j.isci.2022.105145. View

Kim W, Hudson B, Moser B, Guo J, Rong L, Lu Y . Receptor for advanced glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis. Ann N Y Acad Sci. 2005; 1043:553-61. DOI: 10.1196/annals.1338.063. View

Sha W, Shen L, Zhou L, Xu D, Lu G . Down-regulation of miR-186 contributes to podocytes apoptosis in membranous nephropathy. Biomed Pharmacother. 2015; 75:179-84. DOI: 10.1016/j.biopha.2015.07.021. View

10.

Anil Kumar P, Welsh G, Raghu G, Menon R, Saleem M, Reddy G . Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus. Arch Biochem Biophys. 2015; 590:10-19. DOI: 10.1016/j.abb.2015.11.003. View

11.

Fritz G . RAGE: a single receptor fits multiple ligands. Trends Biochem Sci. 2011; 36(12):625-32. DOI: 10.1016/j.tibs.2011.08.008. View

12.

Kopp J, Anders H, Susztak K, Podesta M, Remuzzi G, Hildebrandt F . Podocytopathies. Nat Rev Dis Primers. 2020; 6(1):68. PMC: 8162925. DOI: 10.1038/s41572-020-0196-7. View

13.

Ma J, Chadban S, Zhao C, Chen X, Kwan T, Panchapakesan U . TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy. PLoS One. 2014; 9(5):e97985. PMC: 4026484. DOI: 10.1371/journal.pone.0097985. View

14.

Ha T . High glucose and advanced glycosylated end-products affect the expression of alpha-actinin-4 in glomerular epithelial cells. Nephrology (Carlton). 2006; 11(5):435-41. DOI: 10.1111/j.1440-1797.2006.00668.x. View

15.

Wolf G, Bohlender J, Bondeva T, Roger T, Thaiss F, Wenzel U . Angiotensin II upregulates toll-like receptor 4 on mesangial cells. J Am Soc Nephrol. 2006; 17(6):1585-93. DOI: 10.1681/ASN.2005070699. View

16.

Doublier S, Salvidio G, Lupia E, Ruotsalainen V, Verzola D, Deferrari G . Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes. 2003; 52(4):1023-30. DOI: 10.2337/diabetes.52.4.1023. View

17.

Huber T, Reinhardt H, Exner M, Burger J, Kerjaschki D, Saleem M . Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol. 2002; 168(12):6244-52. DOI: 10.4049/jimmunol.168.12.6244. View

18.

Srivastava T, Sharma M, Yew K, Sharma R, Duncan R, Saleem M . LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile. J Cell Commun Signal. 2012; 7(1):49-60. PMC: 3590361. DOI: 10.1007/s12079-012-0184-0. View

19.

Nakata M, Shimada M, Narita-Kinjo I, Nagawa D, Kitayama K, Hamadate M . PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes. In Vivo. 2021; 35(1):147-153. PMC: 7880774. DOI: 10.21873/invivo.12242. View

20.

Kaverina N, Schweickart R, Chan G, Maggiore J, Eng D, Zeng Y . Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span. Aging (Albany NY). 2023; 15(14):6658-6689. PMC: 10415579. DOI: 10.18632/aging.204897. View