Organic Trace Minerals Enhance the Gut Health of British Shorthair Cats by Regulating the Structure of Intestinal Microbiota

Overview

Journal Metabolites

Publisher MDPI

Date 2024 Sep 27

PMID 39330501

Authors

Yingyue Cui

Mingrui Zhang

Haotian Wang

Tong Yu

Anxuan Zhang

Gang Lin

Yuhan Guo

Yi Wu

Affiliations

Soon will be listed here.

Abstract

Trace minerals are essential for biological processes, including enzyme function, immune response, and hormone synthesis. The study assessed the effects of different dietary trace minerals on the gut health, microbiota composition, and immune function of cats. Eighteen adult British Shorthair cats were divided into three groups receiving inorganic trace minerals (ITM), a 50/50 mix of inorganic and organic trace minerals (ITM + OTM), or organic trace minerals (OTM) for 28 days. The OTM showed enhanced immune capacities, reduced intestinal barrier function, and lower inflammation condition. The OTM altered gut microbiota diversity, with a lower Simpson index and higher Shannon index ( < 0.05). Specifically, the abundance of Bacteroidota, Lachnospiraceae, and Prevotella in the OTM group were higher than the ITM group ( < 0.05). Metabolomic analysis identified 504 differential metabolites between the OTM and ITM groups ( < 0.05, VIP-pred-OPLS-DA > 1), affecting pathways related to steroid hormone biosynthesis and glycerophospholipid metabolism ( < 0.05, VIP-pred-OPLS-DA > 2). Additionally, there was a significant correlation between intestinal microbiota and differential metabolites. To conclude, dietary OTM can modulate the gut metabolite and microbiota composition, enhance immune and intestinal barrier function, and mitigate inflammation in cats, highlighting the benefit of using OTM in feline diet to promote the intestinal and overall health.

References

Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C . The molecular mechanisms of copper metabolism and its roles in human diseases. Pflugers Arch. 2020; 472(10):1415-1429. DOI: 10.1007/s00424-020-02412-2. View

Augustsson A, Qvarforth A, Engstrom E, Paulukat C, Rodushkin I . Trace and major elements in food supplements of different origin: Implications for daily intake levels and health risks. Toxicol Rep. 2021; 8:1067-1080. PMC: 8166911. DOI: 10.1016/j.toxrep.2021.04.012. View

Zhang Y, Li S, Gan R, Zhou T, Xu D, Li H . Impacts of gut bacteria on human health and diseases. Int J Mol Sci. 2015; 16(4):7493-519. PMC: 4425030. DOI: 10.3390/ijms16047493. View

Chang M, Yang S . Metabolic Signature of Hepatic Fibrosis: From Individual Pathways to Systems Biology. Cells. 2019; 8(11). PMC: 6912636. DOI: 10.3390/cells8111423. View

Mo R, Zhang M, Wang H, Liu T, Liu P, Wu Y . Chitosan Enhances Intestinal Health in Cats by Altering the Composition of Gut Microbiota and Metabolites. Metabolites. 2023; 13(4). PMC: 10145270. DOI: 10.3390/metabo13040529. View

Rabee A, Khalil M, Abou Khadiga G, Elmahdy A, Sabra E, Zommara M . Response of rumen fermentation and microbiota to dietary supplementation of sodium selenite and bio-nanostructured selenium in lactating Barki sheep. BMC Vet Res. 2023; 19(1):247. PMC: 10680236. DOI: 10.1186/s12917-023-03799-7. View

Gong J, Xiao M . Effect of Organic Selenium Supplementation on Selenium Status, Oxidative Stress, and Antioxidant Status in Selenium-Adequate Dairy Cows During the Periparturient Period. Biol Trace Elem Res. 2018; 186(2):430-440. DOI: 10.1007/s12011-018-1323-0. View

Suchodolski J . Companion animals symposium: microbes and gastrointestinal health of dogs and cats. J Anim Sci. 2010; 89(5):1520-30. PMC: 7199667. DOI: 10.2527/jas.2010-3377. View

Kursvietiene L, Mongirdiene A, Bernatoniene J, Sulinskiene J, Staneviciene I . Selenium Anticancer Properties and Impact on Cellular Redox Status. Antioxidants (Basel). 2020; 9(1). PMC: 7023255. DOI: 10.3390/antiox9010080. View

10.

Costa M, Sarmento-Ribeiro A, Goncalves A . Zinc: From Biological Functions to Therapeutic Potential. Int J Mol Sci. 2023; 24(5). PMC: 10003636. DOI: 10.3390/ijms24054822. View

11.

Coyte K, Schluter J, Foster K . The ecology of the microbiome: Networks, competition, and stability. Science. 2015; 350(6261):663-6. DOI: 10.1126/science.aad2602. View

12.

Kim H, Kim S, Shin S, Park Y, Nam Y, Kim C . Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications. Transl Neurodegener. 2021; 10(1):49. PMC: 8650380. DOI: 10.1186/s40035-021-00273-y. View

13.

Zhang J, Wang W, Cui X, Zhu P, Li S, Yuan S . Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways. J Ethnopharmacol. 2023; 322:117656. DOI: 10.1016/j.jep.2023.117656. View

14.

Singh S, Anshita D, Ravichandiran V . MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021; 101(Pt B):107598. PMC: 8135227. DOI: 10.1016/j.intimp.2021.107598. View

15.

Schwab I, Nimmerjahn F . Intravenous immunoglobulin therapy: how does IgG modulate the immune system?. Nat Rev Immunol. 2013; 13(3):176-89. DOI: 10.1038/nri3401. View

16.

Cheng S, Huang W, Pang J, Wu Y, Cheng C . Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways. Int J Mol Sci. 2019; 20(12). PMC: 6628093. DOI: 10.3390/ijms20122957. View

17.

Leser T, Molbak L . Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host. Environ Microbiol. 2009; 11(9):2194-206. DOI: 10.1111/j.1462-2920.2009.01941.x. View

18.

Suchodolski J . Intestinal microbiota of dogs and cats: a bigger world than we thought. Vet Clin North Am Small Anim Pract. 2011; 41(2):261-72. PMC: 7132526. DOI: 10.1016/j.cvsm.2010.12.006. View

19.

Tyszko M, Lemanska-Perek A, Smiechowicz J, Tomaszewska P, Biecek P, Gozdzik W . Citrulline, Intestinal Fatty Acid-Binding Protein and the Acute Gastrointestinal Injury Score as Predictors of Gastrointestinal Failure in Patients with Sepsis and Septic Shock. Nutrients. 2023; 15(9). PMC: 10180779. DOI: 10.3390/nu15092100. View

20.

Wang S, Yin J, Liu Y, Jin M, Wang Q, Guo J . An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2. Biomed Pharmacother. 2023; 170:116025. DOI: 10.1016/j.biopha.2023.116025. View