Morphological Changes of the Pituitary Gland in Patients with Irritable Bowel Syndrome Using Magnetic Resonance Imaging

Overview

Journal J Imaging

Publisher MDPI

Specialty Radiology

Date 2024 Sep 27

PMID 39330446

Authors

Jessica Abou Chaaya

Jennifer Abou Chaaya

Batoul Jaafar

Lea Saab

Jad Abou Chaaya

Elie Al Ahmar

Elias Estephan

Affiliations

Soon will be listed here.

Abstract

Irritable bowel syndrome (IBS) is a gastrointestinal functional disorder characterized by unclear underlying mechanisms. Several theories propose that hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis leads to elevated cortisol levels and increased sensitivity of gut wall receptors. Given the absence of prior literature on this topic, our study aimed to investigate the potential for diagnosing IBS based on morphological changes in the pituitary gland, specifically its volume and grayscale intensity. Additionally, we aimed to assess whether factors such as gender, age, and body mass index influence these parameters. This retrospective study involved 60 patients, examining the volume and grayscale characteristics of their pituitary glands in the presence of IBS. Our findings revealed a positive correlation between pituitary gland volume and IBS diagnosis, although no significant correlation was observed with grayscale intensity. Due to the limited existing research and the small sample size of our study, further investigation with a larger cohort is warranted to validate these results.

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