Drug-free Remission of Immune Thrombocytopenic Purpura Following Resection of Perihilar Cholangiocarcinoma: a Case Report

Overview

Journal J Surg Case Rep

Publisher Oxford University Press

Specialty General Surgery

Date 2024 Sep 27

PMID 39329010

Authors

Masayoshi Sakuma

Daigoro Takahashi

Keitaro Kamei

Yuichi Takayama

Takamasa Takahashi

Hiroki Aoyama

Takahiro Hosoi

Atsuyuki Maeda

Affiliations

Soon will be listed here.

Abstract

Immune thrombocytopenic purpura (ITP) is a rare autoimmune disorder. Although secondary ITP, caused by various underlying diseases, including some malignant tumors, has been reported, instances of ITP resolving after successful treatment of the underlying cause are uncommon and noteworthy. Herein, we present a case of a patient with perihilar cholangiocarcinoma (pCCA) and ITP who achieved drug-free remission of ITP following tumor resection. A 76-year-old man presented with pCCA complicated by ITP. Prednisolone treatment successfully managed his thrombocytopenia, allowing for a left hepatopancreatoduodenectomy. ITP relapse did not occur after discontinuation of prednisolone postoperatively. This case suggests that surgical resection of the underlying malignancy may induce remission of secondary ITP associated with pCCA.

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