Antifungal Activity of Indolicidin-derived Peptide In-58 Against and

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Sep 27

PMID 39328314

Authors

Sushan Li

Zhanhan Tang

Zhe Liu

Sha Lv

Chunli Yao

Shuang Wang

Fuqiu Li

Affiliations

Soon will be listed here.

Abstract

In-58, a peptide derived from indolicidin, shows extraordinary antibacterial activity and lower toxicity than indolicidin toward mammalian cells. Here, we investigated the antifungal activity of In-58 against the human pathogen and . In-58 markedly inhibited the growth of isolates in microdilution assays and showed no antagonism with any tested antifungal agent (itraconazole, terbinafine or amphotericin B). Scanning electron microscopy and propidium iodide staining indicated that In-58 alters the cell wall integrity and interacts with DNA, leading to disruption of in a dose-dependent manner. In , the mitochondrial membrane potential decreased and reactive oxygen species increased after treatment with In-58. experiments in the (greater wax moth) larval infection model revealed the effectiveness of In-58 against infection with low toxicity. Our results indicate that In-58 possesses remarkable antifungal activity against and . It has potential as a novel drug for the treatment of sporotrichosis.

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