Prussian Blue Nanotechnology in the Treatment of Spinal Cord Injury: Application and Challenges

Overview

Journal Front Bioeng Biotechnol

Date 2024 Sep 26

PMID 39323764

Authors

XiaoPeng Gu

SongOu Zhang

WeiHu Ma

Affiliations

Soon will be listed here.

Abstract

Spinal cord injury (SCI) is a serious neurological condition that currently lacks effective treatments, placing a heavy burden on both patients and society. Prussian blue nanoparticles exhibit great potential for treating spinal cord injuries due to their excellent physicochemical properties and biocompatibility. These nanoparticles have strong anti-inflammatory and antioxidant capabilities, effectively scavenge free radicals, and reduce oxidative stress damage to cells. Prussian blue nanotechnology shows broad application potential in drug delivery, bioimaging, cancer therapy, anti-inflammatory and oxidative stress treatment, and biosensors. This article reviewed the potential applications of Prussian blue nanotechnology in treating spinal cord injuries, explored the challenges and solutions associated with its application, and discussed the future prospects of this technology in SCI treatment.

References

Zhang R, Zhang K, Li J, Liu Q, Xie J . In vivo tracking of neuronal-like cells by magnetic resonance in rabbit models of spinal cord injury. Neural Regen Res. 2014; 8(36):3373-81. PMC: 4146005. DOI: 10.3969/j.issn.1673-5374.2013.36.002. View

Zhu D, Wu H, Jiang K, Xu Y, Miao Z, Wang H . Zero-Valence Selenium-Enriched Prussian Blue Nanozymes Reconstruct Intestinal Barrier against Inflammatory Bowel Disease via Inhibiting Ferroptosis and T Cells Differentiation. Adv Healthc Mater. 2023; 12(12):e2203160. DOI: 10.1002/adhm.202203160. View

Du X, Hou Y . Hotspots analysis and perspectives of Prussian blue analogues (PBAs) in environment and energy in recent 20 years by CiteSpace. Environ Sci Pollut Res Int. 2022; 30(5):11141-11174. DOI: 10.1007/s11356-022-24600-6. View

Liu K, Dong X, Wang Y, Wu X, Dai H . Dopamine-modified chitosan hydrogel for spinal cord injury. Carbohydr Polym. 2022; 298:120047. DOI: 10.1016/j.carbpol.2022.120047. View

Busquets M, Estelrich J . Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications. Drug Discov Today. 2020; 25(8):1431-1443. DOI: 10.1016/j.drudis.2020.05.014. View

An J, Jiang X, Wang Z, Li Y, Zou Z, Wu Q . Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. Int J Pharm. 2022; 628:122285. DOI: 10.1016/j.ijpharm.2022.122285. View

Wang W, Huang X, Zhang Y, Deng G, Liu X, Fan C . Se@SiO nanocomposites suppress microglia-mediated reactive oxygen species during spinal cord injury in rats. RSC Adv. 2022; 8(29):16126-16138. PMC: 9088170. DOI: 10.1039/c8ra01906a. View

Jendelova P . Therapeutic Strategies for Spinal Cord Injury. Int J Mol Sci. 2018; 19(10). PMC: 6214105. DOI: 10.3390/ijms19103200. View

Fehlings M, Vaccaro A, Wilson J, Singh A, Cadotte D, Harrop J . Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One. 2012; 7(2):e32037. PMC: 3285644. DOI: 10.1371/journal.pone.0032037. View

10.

Tang K, Li X, Hu Y, Zhang X, Lu N, Fang Q . Recent advances in Prussian blue-based photothermal therapy in cancer treatment. Biomater Sci. 2023; 11(13):4411-4429. DOI: 10.1039/d3bm00509g. View

11.

Li W, Han C, Cheng G, Chou S, Liu H, Dou S . Chemical Properties, Structural Properties, and Energy Storage Applications of Prussian Blue Analogues. Small. 2019; 15(32):e1900470. DOI: 10.1002/smll.201900470. View

12.

Gao X, Wang Q, Cheng C, Lin S, Lin T, Liu C . The Application of Prussian Blue Nanoparticles in Tumor Diagnosis and Treatment. Sensors (Basel). 2020; 20(23). PMC: 7730465. DOI: 10.3390/s20236905. View

13.

Pal A, Singh A, Nag T, Chattopadhyay P, Mathur R, Jain S . Iron oxide nanoparticles and magnetic field exposure promote functional recovery by attenuating free radical-induced damage in rats with spinal cord transection. Int J Nanomedicine. 2013; 8:2259-72. PMC: 3693820. DOI: 10.2147/IJN.S44238. View

14.

Lamanna J, Urquia L, Hurtig C, Gutierrez J, Anderson C, Piferi P . Magnetic Resonance Imaging-Guided Transplantation of Neural Stem Cells into the Porcine Spinal Cord. Stereotact Funct Neurosurg. 2017; 95(1):60-68. PMC: 5359976. DOI: 10.1159/000448765. View

15.

Hosseini S, Borys B, Karimi-Abdolrezaee S . Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances. Brain. 2023; 147(3):766-793. DOI: 10.1093/brain/awad392. View

16.

Lin S, Cui J, Li X, Chen S, Gao K, Mei X . Modified ZIF-8 Nanoparticles for Targeted Metabolic Treatment of Acute Spinal Cord Injury. ACS Appl Mater Interfaces. 2024; 16(12):14503-14509. DOI: 10.1021/acsami.3c13984. View

17.

Yang B, Chen Y, Shi J . Reactive Oxygen Species (ROS)-Based Nanomedicine. Chem Rev. 2019; 119(8):4881-4985. DOI: 10.1021/acs.chemrev.8b00626. View

18.

Liu Y, Wang C, Kong X, Wang H, Chang J, Zhang D . Novel multifunctional polyethylene glycol-transactivating-transduction protein-modified liposomes cross the blood-spinal cord barrier after spinal cord injury. J Drug Target. 2009; 18(6):420-9. DOI: 10.3109/10611860903434001. View

19.

Fan B, Wei Z, Yao X, Shi G, Cheng X, Zhou X . Microenvironment Imbalance of Spinal Cord Injury. Cell Transplant. 2018; 27(6):853-866. PMC: 6050904. DOI: 10.1177/0963689718755778. View

20.

Miao X, Lin J, Li A, Gao T, Liu T, Shen J . AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling. Exp Neurol. 2024; 375:114739. DOI: 10.1016/j.expneurol.2024.114739. View