Bartonella Spp. in Phlebotominae Sand Flies, Brazil

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2024 Sep 25

PMID 39320166

Authors

Daniel Antonio Braga Lee

Paloma Helena Fernandes Shimabukuro

Andreia Fernandes Brilhante

Paulo Vitor Cadina Arantes

Gustavo Seron Sanches

Eliz Oliveira Franco

Rosangela Zacarias Machado

Ricardo G Maggi

Edward B Breitschwerdt

Marcos Rogerio Andre

Affiliations

Soon will be listed here.

Abstract

Bartonella spp. are opportunistic, vectorborne bacteria that can cause disease in both animals and humans. We investigated the molecular occurrence of Bartonella spp. in 634 phlebotomine sand fly specimens, belonging to 44 different sand fly species, sampled during 2017-2021 in north and northeastern Brazil. We detected Bartonella sp. DNA in 8.7% (55/634) of the specimens by using a quantitative real-time PCR targeting the 16S-23S internal transcribed spacer intergenic region. Phylogenetic analysis positioned the Lutzomyia longipalpis sand fly-associated Bartonella gltA gene sequence in the same subclade as Bartonella ancashensis sequences and revealed a Bartonella sp. sequence in a Dampfomyia beltrani sand fly from Mexico. We amplified a bat-associated Bartonella nuoG sequence from a specimen of Nyssomyia antunesi sand fly. Our findings document the presence of Bartonella DNA in sand flies from Brazil, suggesting possible involvement of these insects in the epidemiologic cycle of Bartonella species.

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