Inflammatory and Immune Mechanisms in COPD: Current Status and Therapeutic Prospects

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2024 Sep 25

PMID 39318994

Authors

Yanan Qi

Yuanyuan Yan

Dawei Tang

JingJing Han

Xinyi Zhu

Mengting Cui

Hongyan Wu

Yu Tao

Fangtian Fan

Affiliations

Soon will be listed here.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) currently ranks among the top three causes of mortality worldwide, presenting as a prevalent and complex respiratory ailment. Ongoing research has underscored the pivotal role of immune function in the onset and progression of COPD. The immune response in COPD patients exhibits abnormalities, characterized by diminished anti-infection capacity due to immune senescence, heightened activation of neutrophils and macrophages, T cell infiltration, and aberrant B cell activity, collectively contributing to airway inflammation and lung injury in COPD.

Objective: This review aimed to explore the pivotal role of the immune system in COPD and its therapeutic potential.

Methods: We conducted a review of immunity and COPD published within the past decade in the Web of Science and PubMed databases, sorting through and summarizing relevant literature.

Results: This article examines the pivotal roles of the immune system in COPD. Understanding the specific functions and interactions of these immune cells could facilitate the development of novel therapeutic strategies and interventions aimed at controlling inflammation, enhancing immune function, and mitigating the impact of respiratory infections in COPD patients.

References

Cazzola M, Hanania N, Page C, Matera M . Novel Anti-Inflammatory Approaches to COPD. Int J Chron Obstruct Pulmon Dis. 2023; 18:1333-1352. PMC: 10318108. DOI: 10.2147/COPD.S419056. View

Alisjahbana A, Mohammad I, Gao Y, Evren E, Ringqvist E, Willinger T . Human macrophages and innate lymphoid cells: Tissue-resident innate immunity in humanized mice. Biochem Pharmacol. 2019; 174:113672. DOI: 10.1016/j.bcp.2019.113672. View

Venkatesan P . GOLD COPD report: 2024 update. Lancet Respir Med. 2023; 12(1):15-16. DOI: 10.1016/S2213-2600(23)00461-7. View

Lokwani R, Wark P, Baines K, Fricker M, Barker D, Simpson J . Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression. Int J Chron Obstruct Pulmon Dis. 2019; 14:2517-2525. PMC: 6863133. DOI: 10.2147/COPD.S222486. View

Rabe K, Watz H . Chronic obstructive pulmonary disease. Lancet. 2017; 389(10082):1931-1940. DOI: 10.1016/S0140-6736(17)31222-9. View

Chapman N, Boothby M, Chi H . Metabolic coordination of T cell quiescence and activation. Nat Rev Immunol. 2019; 20(1):55-70. DOI: 10.1038/s41577-019-0203-y. View

Li J, Zhao L, Zhang Y, Li W, Duan X, Chen J . Imbalanced immune responses involving inflammatory molecules and immune-related pathways in the lung of acute and subchronic arsenic-exposed mice. Environ Res. 2017; 159:381-393. DOI: 10.1016/j.envres.2017.08.036. View

Kaur M, Chandel J, Malik J, Naura A . Particulate matter in COPD pathogenesis: an overview. Inflamm Res. 2022; 71(7-8):797-815. DOI: 10.1007/s00011-022-01594-y. View

Koreny M, Arbillaga-Etxarri A, de Basea M, Foraster M, Carsin A, Cirach M . Urban environment and physical activity and capacity in patients with chronic obstructive pulmonary disease. Environ Res. 2022; 214(Pt 2):113956. DOI: 10.1016/j.envres.2022.113956. View

10.

Bridgewood C, Newton D, Bragazzi N, Wittmann M, McGonagle D . Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis. Semin Immunol. 2021; 58:101520. DOI: 10.1016/j.smim.2021.101520. View

11.

Yousefzadeh M, Flores R, Zhu Y, Schmiechen Z, Brooks R, Trussoni C . An aged immune system drives senescence and ageing of solid organs. Nature. 2021; 594(7861):100-105. PMC: 8684299. DOI: 10.1038/s41586-021-03547-7. View

12.

. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2020; 8(6):585-596. PMC: 7284317. DOI: 10.1016/S2213-2600(20)30105-3. View

13.

Netea M, Schlitzer A, Placek K, Joosten L, Schultze J . Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens. Cell Host Microbe. 2019; 25(1):13-26. DOI: 10.1016/j.chom.2018.12.006. View

14.

Janjua S, Fortescue R, Poole P . Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2020; 5:CD002309. PMC: 7193764. DOI: 10.1002/14651858.CD002309.pub6. View

15.

Brodin P, Davis M . Human immune system variation. Nat Rev Immunol. 2016; 17(1):21-29. PMC: 5328245. DOI: 10.1038/nri.2016.125. View

16.

Noval Rivas M, Wakita D, Franklin M, Carvalho T, Abolhesn A, Gomez A . Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019; 51(3):508-521.e6. PMC: 6751009. DOI: 10.1016/j.immuni.2019.05.021. View

17.

Zhang Q, Cao X . Epigenetic Remodeling in Innate Immunity and Inflammation. Annu Rev Immunol. 2021; 39:279-311. DOI: 10.1146/annurev-immunol-093019-123619. View

18.

Villasenor-Altamirano A, Jain D, Jeong Y, Menon J, Kamiya M, Haider H . Activation of CD8 T Cells in Chronic Obstructive Pulmonary Disease Lung. Am J Respir Crit Care Med. 2023; 208(11):1177-1195. PMC: 10868372. DOI: 10.1164/rccm.202305-0924OC. View

19.

Kaplanski G . Interleukin-18: Biological properties and role in disease pathogenesis. Immunol Rev. 2017; 281(1):138-153. PMC: 7165732. DOI: 10.1111/imr.12616. View

20.

Thomas R, Qiao S, Yang X . Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases. Int J Mol Sci. 2023; 24(5). PMC: 10003150. DOI: 10.3390/ijms24054865. View